Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome

Gyorgy Petrovics*, Aijun Liu, Syed Shaheduzzaman, Bungo Furasato, Chen Sun, Yongmei Chen, Martin Nau, Lakshmi Ravindranath, Yidong Chen, Albert Dobi, Vasantha Srikantan, Isabell A. Sesterhenn, David G. McLeod, Maryanne Vahey, Judd W. Moul, Shiv Srivastava

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

310 Scopus citations


Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses, and tumorigenesis. This study, analysing laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n = 114; 228 specimen) by GeneChip and quantitative real-time RT-PCR, identifies ETS-related gene (ERG), a member of the ETS transcription factor family, as the most frequently overexpressed proto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all CaP specimen (54 of 55). Comprehensive evaluation of quantitative ERG1 expression with clinicopathological features also suggested that ERG1 expression level in prostate tumor cells relative to benign epithelial cells is indicator of disease-free survival after radical prostatectomy.

Original languageEnglish
Pages (from-to)3847-3852
Number of pages6
Issue number23
StatePublished - 26 May 2005
Externally publishedYes


  • ERG1
  • ETS transcription factor family
  • Overexpression
  • Prostate cancer
  • Proto-oncogene


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