From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

COVID Human Genetic Effort

doi:10.1016/j.jid.2021.05.024

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

COVID Human Genetic Effort

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

Original language	English
Pages (from-to)	2791-2796
Number of pages	6
Journal	Journal of Investigative Dermatology
Volume	141
Issue number	12
DOIs	https://doi.org/10.1016/j.jid.2021.05.024
State	Published - Dec 2021
Externally published	Yes

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10.1016/j.jid.2021.05.024

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@article{2407e1695ddb424dbcddfbd529b2df09,

title = "From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio",

abstract = "Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.",

author = "{COVID Human Genetic Effort} and Arkin, {Lisa M.} and Moon, {John J.} and Tran, {Jennifer M.} and Samira Asgari and Cliona O'Farrelly and Casanova, {Jean Laurent} and Cowen, {Edward W.} and Mays, {Jacqueline W.} and Singh, {Anne Marie} and Drolet, {Beth A.} and Alessandro Aiuti and Alexandre Belot and Alexandre Bolze and Anastasiia Bondarenko and Anna Sediva and Anna Shcherbina and Planas, {Anna M.} and Antonio Condino-Neto and Aurora Pujol and Biggs Catherine and Carlos Flores and Carlos Rodr{\'i}guez-Gallego and Carolina Prando and Dalgard, {Clifton L.} and Cliona O'Farrelly and Colobran Roger and Davoud Mansouri and {van de Beek}, Diederik and Vinh, {Donald C.} and Elena Hsieh and Evangelos Andreakos and Filomeen Haerynck and Furkan Uddin and Giorgio Casari and Giuseppe Novelli and Graziano Pesole and Isabelle Meyts and Ivan Tancevski and Jacques Fellay and Jordi Tur and Kai Kisand and Keisuke Okamoto and Kristina Mironska and Laurent Abel and Laurent Renia and Ng, {Lisa F.P.} and Mohammed Shahrooei and Pere Soler-Palac{\'i}n and Petter Brodin and Qiang Pan-Hammarstr{\"o}m",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = dec,

doi = "10.1016/j.jid.2021.05.024",

language = "English",

volume = "141",

pages = "2791--2796",

journal = "Journal of Investigative Dermatology",

issn = "0022-202X",

number = "12",

}

TY - JOUR

T1 - From Your Nose to Your Toes

T2 - A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

AU - COVID Human Genetic Effort

AU - Arkin, Lisa M.

AU - Moon, John J.

AU - Tran, Jennifer M.

AU - Asgari, Samira

AU - O'Farrelly, Cliona

AU - Casanova, Jean Laurent

AU - Cowen, Edward W.

AU - Mays, Jacqueline W.

AU - Singh, Anne Marie

AU - Drolet, Beth A.

AU - Aiuti, Alessandro

AU - Belot, Alexandre

AU - Bolze, Alexandre

AU - Bondarenko, Anastasiia

AU - Sediva, Anna

AU - Shcherbina, Anna

AU - Planas, Anna M.

AU - Condino-Neto, Antonio

AU - Pujol, Aurora

AU - Catherine, Biggs

AU - Flores, Carlos

AU - Rodríguez-Gallego, Carlos

AU - Prando, Carolina

AU - Dalgard, Clifton L.

AU - O'Farrelly, Cliona

AU - Roger, Colobran

AU - Mansouri, Davoud

AU - van de Beek, Diederik

AU - Vinh, Donald C.

AU - Hsieh, Elena

AU - Andreakos, Evangelos

AU - Haerynck, Filomeen

AU - Uddin, Furkan

AU - Casari, Giorgio

AU - Novelli, Giuseppe

AU - Pesole, Graziano

AU - Meyts, Isabelle

AU - Tancevski, Ivan

AU - Fellay, Jacques

AU - Tur, Jordi

AU - Kisand, Kai

AU - Okamoto, Keisuke

AU - Mironska, Kristina

AU - Abel, Laurent

AU - Renia, Laurent

AU - Ng, Lisa F.P.

AU - Shahrooei, Mohammed

AU - Soler-Palacín, Pere

AU - Brodin, Petter

AU - Pan-Hammarström, Qiang

PY - 2021/12

Y1 - 2021/12

N2 - Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

AB - Despite thousands of reported patients with pandemic-associated pernio, low rates of seroconversion and PCR positivity have defied causative linkage to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pernio in uninfected children is associated with monogenic disorders of excessive IFN-1 immunity, whereas severe COVID-19 pneumonia can result from insufficient IFN-1. Moreover, SARS-CoV-2 spike protein and robust IFN-1 response are seen in the skin of patients with pandemic-associated pernio, suggesting an excessive innate immune skin response to SARS-CoV-2. Understanding the pathophysiology of this phenomenon may elucidate the host mechanisms that drive a resilient immune response to SARS-CoV-2 and could produce relevant therapeutic targets.

UR - http://www.scopus.com/inward/record.url?scp=85115386524&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2021.05.024

DO - 10.1016/j.jid.2021.05.024

M3 - Review article

C2 - 34561087

AN - SCOPUS:85115386524

SN - 0022-202X

VL - 141

SP - 2791

EP - 2796

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

IS - 12

ER -

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio

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