Functional Drug Screening in the Era of Precision Medicine

Giulia C. Napoli, William D. Figg, Cindy H. Chau*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

The focus of precision medicine is providing the right treatment to each unique patient. This scientific movement has incited monumental advances in oncology including the approval of effective, targeted agnostic therapies. Yet, precision oncology has focused largely on genomics in the treatment decision making process, and several recent clinical trials demonstrate that genomics is not the only variable to be considered. Drug screening in three dimensional (3D) models, including patient derived organoids, organs on a chip, xenografts, and 3D-bioprinted models provide a functional medicine perspective and necessary complement to genomic testing. In this review, we discuss the practicality of various 3D drug screening models and each model’s ability to capture the patient’s tumor microenvironment. We highlight the potential for enhancing precision medicine that personalized functional drug testing holds in combination with genomic testing and emerging mathematical models.

Original languageEnglish
Article number912641
JournalFrontiers in Medicine
Volume9
DOIs
StatePublished - 8 Jul 2022
Externally publishedYes

Keywords

  • chemosensitivity
  • drug screening
  • functional medicine
  • organoid
  • precision oncology

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