Furosemide and the progression of left ventricular dysfunction in experimental heart failure

John M. McCurley, Stephen U. Hanlon, Shao Kui Wei, Erich F. Wedam, Michael Michalski, Mark C. Haigney

Research output: Contribution to journalArticlepeer-review

131 Scopus citations


We tested the hypothesis that furosemide accelerates the progression of left ventricular systolic dysfunction in a tachycardia-induced porcine model of heart failure. Furosemide activates the renin-angiotensin-aldosterone system in patients with congestive heart failure (CHF). Such activation may contribute to CHF progression, but prospective data are lacking. Thirty-two Yorkshire pigs were randomized to furosemide (1 mg/kg intramuscularly daily, mean 16.1 ± 0.9 mg) or placebo. Thereafter, a pacing model of heart failure was utilized to produce systolic dysfunction in both sets of animals (fractional shortening <0.16 by echocardiogram). The goal was to determine if furosemide would accelerate the progression of left ventricular dysfunction in the "treated" group. After sacrifice, sodium-calcium exchanger currents and their responsiveness to isoproterenol were measured during voltage clamp. All investigators were blinded to treatment assignment. Furosemide shortened the time to left ventricular dysfunction (35.1 ± 5.1 days in placebo versus 21.4 ± 3.2 days for furosemide animals; p = 0.038, log-rank test). By day 14, aldosterone levels were significantly higher in furosemide animals (43.0 ± 11.8 ng/dl vs. 17.6 ± 4.5 ng/dl; p < 0.05). Serum sodium was reduced (133.0 ± 0.9 mmol/l furosemide vs. 135.7 ± 0.8 mmol/l placebo; p < 0.05), but no difference in norepinephrine, potassium, magnesium, creatinine, or urea nitrogen was present. Basal sodium-calcium exchanger currents were significantly increased and isoproterenol responsiveness depressed by furosemide. Tachycardic pigs given furosemide had significant acceleration of both contractile and metabolic features of CHF, including left ventricular systolic dysfunction, elevated serum aldosterone levels, and altered calcium handling in a controlled experimental model of heart failure.

Original languageEnglish
Pages (from-to)1301-1307
Number of pages7
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - 15 Sep 2004
Externally publishedYes


Dive into the research topics of 'Furosemide and the progression of left ventricular dysfunction in experimental heart failure'. Together they form a unique fingerprint.

Cite this