TY - JOUR
T1 - Gametocyte carriage, antimalarial use, and drug resistance in Cambodia, 2008-2014
AU - Lin, Jessica T.
AU - Patel, Jaymin C.
AU - Levitz, Lauren
AU - Wojnarski, Mariusz
AU - Chaorattanakawee, Suwanna
AU - Gosi, Panita
AU - Buathong, Nillawan
AU - Chann, Soklyda
AU - Huy, Rekol
AU - Thay, Khengheng
AU - Sea, Darapiseth
AU - Samon, Nou
AU - Takala-Harrison, Shannon
AU - Fukuda, Mark
AU - Smith, Philip
AU - Spring, Michele
AU - Saunders, David
AU - Lon, Chanthap
N1 - Publisher Copyright:
Copyright © 2018 by The American Society of Tropical Medicine and Hygiene
PY - 2018
Y1 - 2018
N2 - Gametocytes are the malaria parasite stages responsible for transmission from humans to mosquitoes. Gametocytemia often follows drug treatment, especially as therapies start to fail. We examined Plasmodium falciparum gametocyte carriage and drug resistance profiles among 824 persons with uncomplicated malaria in Cambodia to determine whether prevalent drug resistance and antimalarial use has led to a concentration of drug-resistant parasites among gametocyte carriers. Although report of prior antimalarial use increased from 2008 to 2014, the prevalence of study participants presenting with microscopic gametocyte carriage declined. Gametocytemia was more common in those reporting antimalarial use within the past year, and prior antimalarial use was correlated with higher IC50s to piperaquine and mefloquine, as well as to increased pfmdr1 copy number. However, there was no association between microscopic gametocyte carriage and parasite drug resistance. Thus, we found no evidence that the infectious reservoir, marked by those carrying gametocytes, is enriched with drug-resistant parasites.
AB - Gametocytes are the malaria parasite stages responsible for transmission from humans to mosquitoes. Gametocytemia often follows drug treatment, especially as therapies start to fail. We examined Plasmodium falciparum gametocyte carriage and drug resistance profiles among 824 persons with uncomplicated malaria in Cambodia to determine whether prevalent drug resistance and antimalarial use has led to a concentration of drug-resistant parasites among gametocyte carriers. Although report of prior antimalarial use increased from 2008 to 2014, the prevalence of study participants presenting with microscopic gametocyte carriage declined. Gametocytemia was more common in those reporting antimalarial use within the past year, and prior antimalarial use was correlated with higher IC50s to piperaquine and mefloquine, as well as to increased pfmdr1 copy number. However, there was no association between microscopic gametocyte carriage and parasite drug resistance. Thus, we found no evidence that the infectious reservoir, marked by those carrying gametocytes, is enriched with drug-resistant parasites.
UR - http://www.scopus.com/inward/record.url?scp=85056287405&partnerID=8YFLogxK
U2 - 10.4269/AJTMH.18-0509
DO - 10.4269/AJTMH.18-0509
M3 - Article
C2 - 30226145
AN - SCOPUS:85056287405
SN - 0002-9637
VL - 99
SP - 1145
EP - 1149
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 5
ER -