Gene therapeutic approaches to induction and maintenance of tolerance

M. E.F. Melo*, M. El-Amine, L. Tonnetti, L. Fleischman, D. W. Scott

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Tolerance induction would be an ideal way to treat autoimmune diseases, especially if achievable in primed individuals. Moreover, specific tolerance would preclude the need for immunosuppressive treatment with its side effects. In this review, we will revisit the historical concepts of tolerance, and introduce a novel approach to tolerance via gene therapy. Our model system is based on the tolerogenicity of IgG carriers and B-cell antigen presentation. Results with this model demonstrate that it is simple and effective even in primed recipients, and has proven efficacy in three autoimmune models. We discuss the mechanisms of tolerance with fusion IgG's and analyze how our model of gene therapy approached can be utilized to fit in the future treatment of autoimmune conditions.

Original languageEnglish
Pages (from-to)627-645
Number of pages19
JournalInternational Reviews of Immunology
Issue number5
StatePublished - 2001
Externally publishedYes


  • Autoimmunity
  • B-cell presentation
  • Gene therapy
  • IgG fusion proteins


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