Genetic analysis of experimentally induced lupus in mice

Edna Mozes; David Alling; Matthew W. Miller; Susan M. Payne; Heidy Zinger; Charles S. Via; Gene M. Shearer

doi:10.1006/clin.1997.4423

Genetic analysis of experimentally induced lupus in mice

Edna Mozes^*
, David Alling
, Matthew W. Miller
, Susan M. Payne
, Heidy Zinger
, Charles S. Via
, Gene M. Shearer

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. By both approaches the BXD RI lines could be divided into distinct DBA/2-like and C57BL/6-like categories. Concordance of SLE induced by both methods was observed for susceptibility and resistance in 13/15 BXD lines (P < 0.005). The results suggest that at least two non-H-2 genes control susceptibility and resistance to experimentally induced SLE, one mapping to chromosome 7 and the other mapping to chromosome 14.

Original language	English
Pages (from-to)	28-34
Number of pages	7
Journal	Clinical Immunology and Immunopathology
Volume	85
Issue number	1
DOIs	https://doi.org/10.1006/clin.1997.4423
State	Published - Oct 1997

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@article{ee91da6908754ccd96d16bf40fd5188b,

title = "Genetic analysis of experimentally induced lupus in mice",

abstract = "The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. By both approaches the BXD RI lines could be divided into distinct DBA/2-like and C57BL/6-like categories. Concordance of SLE induced by both methods was observed for susceptibility and resistance in 13/15 BXD lines (P < 0.005). The results suggest that at least two non-H-2 genes control susceptibility and resistance to experimentally induced SLE, one mapping to chromosome 7 and the other mapping to chromosome 14.",

author = "Edna Mozes and David Alling and Miller, \{Matthew W.\} and Payne, \{Susan M.\} and Heidy Zinger and Via, \{Charles S.\} and Shearer, \{Gene M.\}",

year = "1997",

month = oct,

doi = "10.1006/clin.1997.4423",

language = "English",

volume = "85",

pages = "28--34",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

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TY - JOUR

T1 - Genetic analysis of experimentally induced lupus in mice

AU - Mozes, Edna

AU - Alling, David

AU - Miller, Matthew W.

AU - Payne, Susan M.

AU - Zinger, Heidy

AU - Via, Charles S.

AU - Shearer, Gene M.

PY - 1997/10

Y1 - 1997/10

N2 - The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. By both approaches the BXD RI lines could be divided into distinct DBA/2-like and C57BL/6-like categories. Concordance of SLE induced by both methods was observed for susceptibility and resistance in 13/15 BXD lines (P < 0.005). The results suggest that at least two non-H-2 genes control susceptibility and resistance to experimentally induced SLE, one mapping to chromosome 7 and the other mapping to chromosome 14.

AB - The DBA/2 and C57BL/6 mouse strains, as well as the BXD RI lines derived from these strains, were used to map the genes controlling experimentally induced systemic lupus erythematosus (SLE). SLE was induced using two immunologic approaches: (1) immunization with the human monoclonal anti-DNA antibody expressing the 16/6Id, to which the DBA/2 strain is susceptible (responder) and the C57BL/6 strain is resistant (nonresponder); and (2) induction of autoimmune GVHD in B6D2F1 hosts by inoculation of parental DBA/2 (induces SLE) or C57BL/6 (does not induce SLE) T cells. By both approaches the BXD RI lines could be divided into distinct DBA/2-like and C57BL/6-like categories. Concordance of SLE induced by both methods was observed for susceptibility and resistance in 13/15 BXD lines (P < 0.005). The results suggest that at least two non-H-2 genes control susceptibility and resistance to experimentally induced SLE, one mapping to chromosome 7 and the other mapping to chromosome 14.

UR - https://www.scopus.com/pages/publications/0031260030

U2 - 10.1006/clin.1997.4423

DO - 10.1006/clin.1997.4423

M3 - Article

C2 - 9325066

AN - SCOPUS:0031260030

SN - 0090-1229

VL - 85

SP - 28

EP - 34

JO - Clinical Immunology and Immunopathology

JF - Clinical Immunology and Immunopathology

IS - 1

ER -

Genetic analysis of experimentally induced lupus in mice

Abstract

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