Abstract
Scientific approaches for studying the genetics underlying depression and antidepressant responses using available animal models are reviewed. Numerous examples of genetically defined inbred rodent strains with divergent responses on tests of depressive behavior provide opportunities to identify genes that may influence the risk of major depressive disorder (MDD). Rodent strains that differ dramatically in behavioral responses to pharmacologically distinct classes of antidepressants can be used to identify genes that might predict either sensitivity or resistance to the therapeutic effects of drugs in MDD. Rodent strains with deficient monoamine synthesis have been used to study the pathology of MDD and the mechanism of drugs used to treat MDD.
| Original language | English |
|---|---|
| Title of host publication | Depression |
| Subtitle of host publication | From Psychopathology to Pharmacotherapy |
| Publisher | S. Karger AG |
| Pages | 139-154 |
| Number of pages | 16 |
| Volume | 27 |
| ISBN (Electronic) | 9783805596060 |
| ISBN (Print) | 9783805596053 |
| DOIs | |
| State | Published - 17 Nov 2010 |
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver