Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

Nisha Thakur; Showket Hussain; Indu Kohaar; Rubina Tabassum; Vilas Nasare; Pratibha Tiwari; Swaraj Batra; Suresh Bhambhani; Bhudev C. Das; Seemi Farhat Basir; Dwaipayan Bharadwaj; Mausumi Bharadwaj

doi:10.1080/13547500902825274

Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

Nisha Thakur, Showket Hussain, Indu Kohaar, Rubina Tabassum, Vilas Nasare, Pratibha Tiwari, Swaraj Batra, Suresh Bhambhani, Bhudev C. Das, Seemi Farhat Basir, Dwaipayan Bharadwaj, Mausumi Bharadwaj^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.514.09; p0.0004) compared with GGGA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p0.019; OR 0.71; 95% CI 0.540.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.

Original language	English
Pages (from-to)	219-225
Number of pages	7
Journal	Biomarkers
Volume	14
Issue number	4
DOIs	https://doi.org/10.1080/13547500902825274
State	Published - Jun 2009
Externally published	Yes

Keywords

Cervical cancer
Cyclin D1
G1722C
G870A
Human papillomavirus
Single nucleotide polymorphism

Access to Document

10.1080/13547500902825274

Cite this

@article{5013aad8d9b34df0992d4afc1ffa4933,

title = "Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population",

abstract = "The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.514.09; p0.0004) compared with GGGA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p0.019; OR 0.71; 95% CI 0.540.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.",

keywords = "Cervical cancer, Cyclin D1, G1722C, G870A, Human papillomavirus, Single nucleotide polymorphism",

author = "Nisha Thakur and Showket Hussain and Indu Kohaar and Rubina Tabassum and Vilas Nasare and Pratibha Tiwari and Swaraj Batra and Suresh Bhambhani and Das, {Bhudev C.} and Basir, {Seemi Farhat} and Dwaipayan Bharadwaj and Mausumi Bharadwaj",

note = "Funding Information: The authors thank patients and their relatives for their support and cooperation. The study was supported by core funds of ICPO (ICMR), Noida.",

year = "2009",

month = jun,

doi = "10.1080/13547500902825274",

language = "English",

volume = "14",

pages = "219--225",

journal = "Biomarkers",

issn = "1354-750X",

number = "4",

}

TY - JOUR

T1 - Genetic variant of CCND1

T2 - Association with HPV-mediated cervical cancer in Indian population

AU - Thakur, Nisha

AU - Hussain, Showket

AU - Kohaar, Indu

AU - Tabassum, Rubina

AU - Nasare, Vilas

AU - Tiwari, Pratibha

AU - Batra, Swaraj

AU - Bhambhani, Suresh

AU - Das, Bhudev C.

AU - Basir, Seemi Farhat

AU - Bharadwaj, Dwaipayan

AU - Bharadwaj, Mausumi

N1 - Funding Information: The authors thank patients and their relatives for their support and cooperation. The study was supported by core funds of ICPO (ICMR), Noida.

PY - 2009/6

Y1 - 2009/6

N2 - The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.514.09; p0.0004) compared with GGGA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p0.019; OR 0.71; 95% CI 0.540.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.

AB - The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.514.09; p0.0004) compared with GGGA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p0.019; OR 0.71; 95% CI 0.540.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.

KW - Cervical cancer

KW - Cyclin D1

KW - G1722C

KW - G870A

KW - Human papillomavirus

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=68549137888&partnerID=8YFLogxK

U2 - 10.1080/13547500902825274

DO - 10.1080/13547500902825274

M3 - Article

C2 - 19489683

AN - SCOPUS:68549137888

SN - 1354-750X

VL - 14

SP - 219

EP - 225

JO - Biomarkers

JF - Biomarkers

IS - 4

ER -

Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

Abstract

Keywords

Access to Document

Fingerprint

Cite this