Genetic variant of CCND1: Association with HPV-mediated cervical cancer in Indian population

Nisha Thakur, Showket Hussain, Indu Kohaar, Rubina Tabassum, Vilas Nasare, Pratibha Tiwari, Swaraj Batra, Suresh Bhambhani, Bhudev C. Das, Seemi Farhat Basir, Dwaipayan Bharadwaj, Mausumi Bharadwaj*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The potential association of single nucleotide polymorphisms (SNPs) (G870A and G1722C) of CCND1 with susceptibility to cervical cancer was investigated. The study included 200 cervical cancer cases along with an equal number of healthy controls. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and direct sequencing were employed for genotyping. We found that women carrying the 870AA genotype have a 2.49-fold increased risk for the development of cervical cancer (odds ratio (OR) 2.49; 95% confidence interval (CI) 1.514.09; p0.0004) compared with GGGA genotypes. For the 1722 locus, the frequency of the polymorphic 'C' allele was strongly associated with a reduced risk of cervical cancer (p0.019; OR 0.71; 95% CI 0.540.94). Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. And G1722C polymorphism may play a protective role against the development of human papillomavirus-associated cervical cancer among Indian women.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
Issue number4
StatePublished - Jun 2009
Externally publishedYes


  • Cervical cancer
  • Cyclin D1
  • G1722C
  • G870A
  • Human papillomavirus
  • Single nucleotide polymorphism


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