Genome-scale, functional screen of Plasmodium sexual replication

Surendra K. Prajapati; Kim C. Williamson

doi:10.1016/j.pt.2024.12.014

Genome-scale, functional screen of Plasmodium sexual replication

Surendra K. Prajapati, Kim C. Williamson^*

^*Corresponding author for this work

Microbiology and Immunology

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Malaria mortality remains above 500 000 people annually, demonstrating the need for new and innovative control approaches. Using a genome-scale, functional screen of Plasmodium sexual replication, Sayers et al. identified over 300 genes essential for malaria transmission through the mosquito, providing many new candidates for drug and vaccine development.

Original language	English
Pages (from-to)	80-82
Number of pages	3
Journal	Trends in Parasitology
Volume	41
Issue number	2
DOIs	https://doi.org/10.1016/j.pt.2024.12.014
State	Published - Feb 2025

Keywords

SUN1
axoneme
fertilization
gametogenesis
malaria transmission
mitochondria

Access to Document

10.1016/j.pt.2024.12.014

Cite this

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title = "Genome-scale, functional screen of Plasmodium sexual replication",

abstract = "Malaria mortality remains above 500 000 people annually, demonstrating the need for new and innovative control approaches. Using a genome-scale, functional screen of Plasmodium sexual replication, Sayers et al. identified over 300 genes essential for malaria transmission through the mosquito, providing many new candidates for drug and vaccine development.",

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AB - Malaria mortality remains above 500 000 people annually, demonstrating the need for new and innovative control approaches. Using a genome-scale, functional screen of Plasmodium sexual replication, Sayers et al. identified over 300 genes essential for malaria transmission through the mosquito, providing many new candidates for drug and vaccine development.

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