Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand

Frédéric Poly; Timothy Read; David R. Tribble; Shahida Baqar; Maria Lorenzo; Patricia Guerry

doi:10.1128/IAI.00050-07

Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand

Frédéric Poly, Timothy Read, David R. Tribble, Shahida Baqar, Maria Lorenzo, Patricia Guerry^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

Original language	English
Pages (from-to)	3425-3433
Number of pages	9
Journal	Infection and Immunity
Volume	75
Issue number	7
DOIs	https://doi.org/10.1128/IAI.00050-07
State	Published - Jul 2007
Externally published	Yes

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title = "Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand",

abstract = "Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.",

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AU - Poly, Frédéric

AU - Read, Timothy

AU - Tribble, David R.

AU - Baqar, Shahida

AU - Lorenzo, Maria

AU - Guerry, Patricia

PY - 2007/7

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AB - Campylobacter jejuni CG8486, which belongs to the HS4 complex, was isolated from a patient with inflammatory diarrhea in Thailand. This strain caused a diarrheal disease in ferrets comparable to that caused by C. jejuni strain 81-176, but it was much less invasive for epithelial cells in vitro than 81-176. Complete genome sequencing of CG8486 revealed a 1.65-Mb genome that was very similar to the other two published genomes of clinical isolates of C. jejuni, the genomes of 81-176 and NCTC 11168, with a limited number of CG8486-specific genes mapping outside the hypervariable carbohydrate biosynthesis loci. These data suggest that the genes required for induction of inflammatory diarrhea are among the genes shared by CG8486 and 81-176 but that either major changes in the carbohydrate loci and/or more subtle changes in other genes may modulate virulence.

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Genome sequence of a clinical isolate of Campylobacter jejuni from Thailand

Abstract

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