TY - JOUR
T1 - Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
AU - Artemisinin Resistance Confirmation, Characterization, and Containment (ARC3)
AU - Artemisinin Resistance Containment and Elimination (ARCE)
AU - Tracking Resistance to Artemisinin Collaboration (TRAC)
AU - Shetty, Amol C.
AU - Jacob, Christopher G.
AU - Huang, Fang
AU - Li, Yao
AU - Agrawal, Sonia
AU - Saunders, David L.
AU - Lon, Chanthap
AU - Fukuda, Mark M.
AU - Ringwald, Pascal
AU - Ashley, Elizabeth A.
AU - Han, Kay Thwe
AU - Hlaing, Tin Maung
AU - Nyunt, Myaing M.
AU - Silva, Joana C.
AU - Stewart, Kathleen E.
AU - Plowe, Christopher V.
AU - O’Connor, Timothy D.
AU - Takala-Harrison, Shannon
AU - Noedl, Harald
AU - Khan, Wasif A.
AU - Newton, Paul
AU - Kyaw, Myat P.
AU - White, Nicholas J.
AU - Dondorp, Arjen M.
AU - Day, Nicholas P.
AU - Woodrow, Charles J.
AU - Dhorda, Mehul
AU - Faiz, M. Abul
AU - Fairhurst, Rick M.
AU - Lim, Pharath
AU - Tripura, Rupam
AU - Mayxay, Mayfong
AU - Htut, Ye
AU - Nosten, Francois
AU - Phyo, Aung Pyae
AU - Pukrittayakamee, Sasithon
AU - Hien, Tran Tinh
AU - Nhien, Nguyen Thanh Thuy
AU - Mokuolu, Olugbenga A.
AU - Fanello, Caterina I.
AU - Onyamboko, Marie A.
N1 - Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
AB - Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites.
UR - http://www.scopus.com/inward/record.url?scp=85067602013&partnerID=8YFLogxK
U2 - 10.1038/s41467-019-10121-3
DO - 10.1038/s41467-019-10121-3
M3 - Article
C2 - 31209259
AN - SCOPUS:85067602013
SN - 2041-1723
VL - 10
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 2665
ER -