Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon

Crystyan Siles; William H. Elson; Stalin Vilcarromero; Amy C. Morrison; Robert D. Hontz; Freddy Alava; Hugo Valdivia; Vidal Felices; Carolina Guevara; Sarah Jenkins; Eugenio J. Abente; Julia S. Ampuero

doi:10.3201/eid2604.191104

Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon

Crystyan Siles^*, William H. Elson, Stalin Vilcarromero, Amy C. Morrison, Robert D. Hontz, Freddy Alava, Hugo Valdivia, Vidal Felices, Carolina Guevara, Sarah Jenkins, Eugenio J. Abente, Julia S. Ampuero

^*Corresponding author for this work

Preventive Medicine and Biostatistics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.

Original language	English
Pages (from-to)	731-737
Number of pages	7
Journal	Emerging Infectious Diseases
Volume	26
Issue number	4
DOIs	https://doi.org/10.3201/eid2604.191104
State	Published - Apr 2020

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Cite this

@article{81dd3fd61479423680c8433845b988d9,

title = "Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon",

abstract = "During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.",

author = "Crystyan Siles and Elson, {William H.} and Stalin Vilcarromero and Morrison, {Amy C.} and Hontz, {Robert D.} and Freddy Alava and Hugo Valdivia and Vidal Felices and Carolina Guevara and Sarah Jenkins and Abente, {Eugenio J.} and Ampuero, {Julia S.}",

year = "2020",

month = apr,

doi = "10.3201/eid2604.191104",

language = "English",

volume = "26",

pages = "731--737",

journal = "Emerging Infectious Diseases",

issn = "1080-6040",

publisher = "Centers for Disease Control and Prevention (CDC)",

number = "4",

}

TY - JOUR

T1 - Guaroa Virus and Plasmodium vivax Co-Infections, Peruvian Amazon

AU - Siles, Crystyan

AU - Elson, William H.

AU - Vilcarromero, Stalin

AU - Morrison, Amy C.

AU - Hontz, Robert D.

AU - Alava, Freddy

AU - Valdivia, Hugo

AU - Felices, Vidal

AU - Guevara, Carolina

AU - Jenkins, Sarah

AU - Abente, Eugenio J.

AU - Ampuero, Julia S.

PY - 2020/4

Y1 - 2020/4

N2 - During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.

AB - During April–June 2014 in a malaria-endemic rural community close to the city of Iquitos in Peru, we detected evidence of Guaroa virus (GROV) infection in 14 febrile persons, of whom 6 also had evidence of Plasmodium vivax malaria. Cases were discovered through a long-term febrile illness surveillance network at local participating health facilities. GROV cases were identified by using a combination of seroconversion and virus isolation, and malaria was diagnosed by thick smear and PCR. GROV mono-infections manifested as nonspecific febrile illness and were clinically indistinguishable from GROV and P. vivax co-infections. This cluster of cases highlights the potential for GROV transmission in the rural Peruvian Amazon, particularly in areas where malaria is endemic. Further study of similar areas of the Amazon may provide insights into the extent of GROV transmission in the Amazon basin.

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DO - 10.3201/eid2604.191104

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JO - Emerging Infectious Diseases

JF - Emerging Infectious Diseases

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