TY - JOUR
T1 - Health-related quality of life among military HIV patients on antiretroviral therapy
AU - Infectious Disease Clinical Research Program HIV Working Group
AU - Emuren, Leonard
AU - Welles, Seth
AU - Evans, Alison A.
AU - Polansky, Marcia
AU - Okulicz, Jason F.
AU - Macalino, Grace
AU - Agan, Brian K.
AU - Chambers, S.
AU - Fairchok, M.
AU - Kunz, A.
AU - Schofield, C.
AU - Powers, J.
AU - Tramont, E.
AU - Banks, S.
AU - Kronmann, K.
AU - Lalani, T.
AU - St Clair, K.
AU - Tant, R.
AU - Bavaro, M.
AU - Deiss, R.
AU - Diem, A.
AU - Kirkland, N.
AU - Maves, R.
AU - Merritt, S.
AU - O'Bryan, T.
AU - Okulicz, J.
AU - Rhodes, C.
AU - Wessely, J.
AU - Ferguson, T.
AU - Hawley-Molloy, J.
AU - Byrne, M.
AU - Chu, X.
AU - Glancey, M.
AU - Macalino, G.
AU - Parmelee, E.
AU - Pavlin, J.
AU - Wang, X.
AU - Won, S.
AU - Wright, P.
AU - Peel, S.
AU - Blaylock, J.
AU - Burris, H.
AU - Decker, C.
AU - Ganesan, A.
AU - Ressner, R.
AU - Wallace, D.
AU - Whitman, T.
N1 - Publisher Copyright:
© This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
PY - 2017/6
Y1 - 2017/6
N2 - Objective: The aims of this study were: (i) to determine the factors associated with HRQOL at baseline in our cohort, and (ii) to evaluate if there are differences in baseline HRQOL measures by antiretroviral treatment. Methods: The Short Form 36 (SF-36) was administered between 2006 and 2010 among members of the United States HIV Natural History Study cohort (NHS), and participants who completed the SF-36 were included in the study. Physical component summary (PCS) and mental component summary (MCS) scores were computed based on standard algorithms. Multivariate linear regression models were constructed for PCS and MCS to estimate the association between selected variables and HRQOL scores. Results: Antiretroviral therapy (ART) was not independently associated with HRQOL scores. Factors associated with PCS were CD4+ count < 200 cells/mm3 (β = -5.84, 95% CI: -7.63, -4.06), mental comorbidity (β = -2.82, 95% CI: -3.79, -1.85), medical comorbidity (β = -2.51, 95% CI: -3.75, -1.27), AIDS diagnosis (β = -2.38, 95% CI: -3.79, -0.98). Others were gender, military rank, marital status, and age. Factors independently associated with MCS were CD4+ count < 200 cells/mm3 (β = -1.93, 95% CI: -3.85, -0.02), mental comorbidity (β = -6.25, 95% CI: -7.25, -5.25), age (β = 0.37, 95% CI: 0.14, 0.60), and being African American (β = 1.55, 95% CI: 0.63, 2.47). Conclusion: Among military active duty and beneficiaries with HIV, modifiable factors associated with HRQOL measures included advanced HIV disease, and mental or medical comorbidity. Addressing these factors may improve quality of life of HIV-infected individuals in the NHS cohort.
AB - Objective: The aims of this study were: (i) to determine the factors associated with HRQOL at baseline in our cohort, and (ii) to evaluate if there are differences in baseline HRQOL measures by antiretroviral treatment. Methods: The Short Form 36 (SF-36) was administered between 2006 and 2010 among members of the United States HIV Natural History Study cohort (NHS), and participants who completed the SF-36 were included in the study. Physical component summary (PCS) and mental component summary (MCS) scores were computed based on standard algorithms. Multivariate linear regression models were constructed for PCS and MCS to estimate the association between selected variables and HRQOL scores. Results: Antiretroviral therapy (ART) was not independently associated with HRQOL scores. Factors associated with PCS were CD4+ count < 200 cells/mm3 (β = -5.84, 95% CI: -7.63, -4.06), mental comorbidity (β = -2.82, 95% CI: -3.79, -1.85), medical comorbidity (β = -2.51, 95% CI: -3.75, -1.27), AIDS diagnosis (β = -2.38, 95% CI: -3.79, -0.98). Others were gender, military rank, marital status, and age. Factors independently associated with MCS were CD4+ count < 200 cells/mm3 (β = -1.93, 95% CI: -3.85, -0.02), mental comorbidity (β = -6.25, 95% CI: -7.25, -5.25), age (β = 0.37, 95% CI: 0.14, 0.60), and being African American (β = 1.55, 95% CI: 0.63, 2.47). Conclusion: Among military active duty and beneficiaries with HIV, modifiable factors associated with HRQOL measures included advanced HIV disease, and mental or medical comorbidity. Addressing these factors may improve quality of life of HIV-infected individuals in the NHS cohort.
UR - http://www.scopus.com/inward/record.url?scp=85020479702&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0178953
DO - 10.1371/journal.pone.0178953
M3 - Article
C2 - 28591161
AN - SCOPUS:85020479702
SN - 1932-6203
VL - 12
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e0178953
ER -