Hendra and Nipah viruses: Different and dangerous

Bryan T. Eaton; Christopher C. Broder; Deborah Middleton; Lin Fa Wang

doi:10.1038/nrmicro1323

Hendra and Nipah viruses: Different and dangerous

Bryan T. Eaton^*, Christopher C. Broder, Deborah Middleton, Lin Fa Wang

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

395 Scopus citations

Abstract

Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens.

Original language	English
Pages (from-to)	23-35
Number of pages	13
Journal	Nature Reviews Microbiology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1038/nrmicro1323
State	Published - Jan 2006
Externally published	Yes

Access to Document

10.1038/nrmicro1323

Cite this

@article{3260d0ac6f7d4b7ea82a81e686a79c92,

title = "Hendra and Nipah viruses: Different and dangerous",

abstract = "Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens.",

author = "Eaton, {Bryan T.} and Broder, {Christopher C.} and Deborah Middleton and Wang, {Lin Fa}",

year = "2006",

month = jan,

doi = "10.1038/nrmicro1323",

language = "English",

volume = "4",

pages = "23--35",

journal = "Nature Reviews Microbiology",

issn = "1740-1526",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Hendra and Nipah viruses

T2 - Different and dangerous

AU - Eaton, Bryan T.

AU - Broder, Christopher C.

AU - Middleton, Deborah

AU - Wang, Lin Fa

PY - 2006/1

Y1 - 2006/1

N2 - Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens.

AB - Hendra virus and Nipah virus are highly pathogenic paramyxoviruses that have recently emerged from flying foxes to cause serious disease outbreaks in humans and livestock in Australia, Malaysia, Singapore and Bangladesh. Their unique genetic constitution, high virulence and wide host range set them apart from other paramyxoviruses. These features led to their classification into the new genus Henipavirus within the family Paramyxoviridae and to their designation as Biosafety Level 4 pathogens. This review provides an overview of henipaviruses and the types of infection they cause, and describes how studies on the structure and function of henipavirus proteins expressed from cloned genes have provided insights into the unique biological properties of these emerging human pathogens.

UR - http://www.scopus.com/inward/record.url?scp=31344481506&partnerID=8YFLogxK

U2 - 10.1038/nrmicro1323

DO - 10.1038/nrmicro1323

M3 - Review article

C2 - 16357858

AN - SCOPUS:31344481506

SN - 1740-1526

VL - 4

SP - 23

EP - 35

JO - Nature Reviews Microbiology

JF - Nature Reviews Microbiology

IS - 1

ER -