Heparin utilization during arterial revascularization

G. J. Collins, D. B. Kimball, N. M. Rich, C. A. Andersen, P. T. McDonald

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


These studies demonstrate that therapeutic levels of heparin are achieved when either 100 u/kg or 150 u/kg are administered prior to arterial or aortic cross clamping during peripheral vascular reconstructive procedures. They further demonstrate that adequate levels of heparin are maintained for at least one hour even with the lower dosage. If heparin effect is not reversed, many patients will be returned to the recovery ward with therapeutic levels of heparin. This is undesirable and can be averted by administering appropriate doses of protamine sulfate. Excesses of protamine sulfate should be avoided since unbound protamine sulfate has anticoagulant as well as cardiovascular effects.

Original languageEnglish
Pages (from-to)753-757
Number of pages5
JournalAmerican Surgeon
Issue number12
StatePublished - 1978
Externally publishedYes


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