Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy

Ryan M. Kwok; Tram T. Tran

doi:10.1016/j.cld.2016.06.005

Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy

Ryan M. Kwok^*, Tram T. Tran

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

10 Scopus citations

Abstract

Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.

Original language	English
Pages (from-to)	693-702
Number of pages	10
Journal	Clinics in Liver Disease
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/j.cld.2016.06.005
State	Published - 1 Nov 2016
Externally published	Yes

Keywords

Chronic hepatitis B
Intrahepatic cholangiocarcinoma
Non-Hodgkin lymphoma
Non–hepatocellular carcinoma malignancy
Pancreatic adenocarcinoma

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title = "Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy",

abstract = "Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.",

keywords = "Chronic hepatitis B, Intrahepatic cholangiocarcinoma, Non-Hodgkin lymphoma, Non–hepatocellular carcinoma malignancy, Pancreatic adenocarcinoma",

author = "Kwok, {Ryan M.} and Tran, {Tram T.}",

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year = "2016",

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day = "1",

doi = "10.1016/j.cld.2016.06.005",

language = "English",

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journal = "Clinics in Liver Disease",

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TY - JOUR

T1 - Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy

AU - Kwok, Ryan M.

AU - Tran, Tram T.

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.

AB - Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.

KW - Chronic hepatitis B

KW - Intrahepatic cholangiocarcinoma

KW - Non-Hodgkin lymphoma

KW - Non–hepatocellular carcinoma malignancy

KW - Pancreatic adenocarcinoma

UR - http://www.scopus.com/inward/record.url?scp=84992168398&partnerID=8YFLogxK

U2 - 10.1016/j.cld.2016.06.005

DO - 10.1016/j.cld.2016.06.005

M3 - Review article

C2 - 27742008

AN - SCOPUS:84992168398

SN - 1089-3261

VL - 20

SP - 693

EP - 702

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

IS - 4

ER -

Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy

Abstract

Keywords

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