TY - JOUR
T1 - Hepatitis B and Risk of Non–Hepatocellular Carcinoma Malignancy
AU - Kwok, Ryan M.
AU - Tran, Tram T.
N1 - Publisher Copyright:
© 2016
PY - 2016/11/1
Y1 - 2016/11/1
N2 - Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.
AB - Chronic hepatitis B infection (CHB) is a known risk factor for malignancy. Unlike hepatocellular carcinoma (HCC), less is known about the risk of non-HCC malignancy. However, epidemiology and pathologic evidence suggests a strong association between non-Hodgkin lymphoma and CHB. Data regarding the risk of other malignancies, such as pancreatic adenocarcinoma and intrahepatic cholangiocarcinoma, are mixed. Surveillance and appropriate treatment of infection and malignancy in these patients is essential. Further study of these associations is needed and may bring new insights in the pathogenesis and treatment of these diseases.
KW - Chronic hepatitis B
KW - Intrahepatic cholangiocarcinoma
KW - Non-Hodgkin lymphoma
KW - Non–hepatocellular carcinoma malignancy
KW - Pancreatic adenocarcinoma
UR - http://www.scopus.com/inward/record.url?scp=84992168398&partnerID=8YFLogxK
U2 - 10.1016/j.cld.2016.06.005
DO - 10.1016/j.cld.2016.06.005
M3 - Review article
C2 - 27742008
AN - SCOPUS:84992168398
SN - 1089-3261
VL - 20
SP - 693
EP - 702
JO - Clinics in Liver Disease
JF - Clinics in Liver Disease
IS - 4
ER -