Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

A. Eduarde Silva, Brian J. McMahon*, Alan J. Parkinson, Maria H. Sjogren, Jay H. Hoofnagle, Adrian M. Di Bisceglie

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

Original languageEnglish
Pages (from-to)895-897
Number of pages3
JournalClinical Infectious Diseases
Volume26
Issue number4
DOIs
StatePublished - 1998

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