Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

A. Eduarde Silva; Brian J. McMahon; Alan J. Parkinson; Maria H. Sjogren; Jay H. Hoofnagle; Adrian M. Di Bisceglie

doi:10.1086/513918

Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

A. Eduarde Silva, Brian J. McMahon^*, Alan J. Parkinson, Maria H. Sjogren, Jay H. Hoofnagle, Adrian M. Di Bisceglie

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

Original language	English
Pages (from-to)	895-897
Number of pages	3
Journal	Clinical Infectious Diseases
Volume	26
Issue number	4
DOIs	https://doi.org/10.1086/513918
State	Published - 1998

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@article{2daf3915757f4bb288adf2591579eb64,

title = "Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine",

abstract = "Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.",

author = "{Eduarde Silva}, A. and McMahon, {Brian J.} and Parkinson, {Alan J.} and Sjogren, {Maria H.} and Hoofnagle, {Jay H.} and {Di Bisceglie}, {Adrian M.}",

note = "Funding Information: Received 30 April 1997; revised 18 November 1997. The use of trade names is for identification only and does not imply endorsement by the U.S. Public Health Service or the U.S. Department of Health and Human Services. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service. Financial support: A.E.S. was supported by a scholarship from FAPESP, S{\~a}o Paulo State Government. * Current address: Division of Gastroenterology, Escola Paulista de Medi-cina, S{\~a}o Paulo, Brazil. †Current address: Department of Medicine, St. Louis University Health Sciences Center, St. Louis. Reprints or correspondence: Dr. Brian J. McMahon, Arctic Investigations Program, Centers for Disease Control and Prevention, 4055 Tudor Centre Drive, Anchorage, Alaska 99508-5902.",

year = "1998",

doi = "10.1086/513918",

language = "English",

volume = "26",

pages = "895--897",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

publisher = "Oxford University Press",

number = "4",

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T1 - Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

AU - Eduarde Silva, A.

AU - McMahon, Brian J.

AU - Parkinson, Alan J.

AU - Sjogren, Maria H.

AU - Hoofnagle, Jay H.

AU - Di Bisceglie, Adrian M.

N1 - Funding Information: Received 30 April 1997; revised 18 November 1997. The use of trade names is for identification only and does not imply endorsement by the U.S. Public Health Service or the U.S. Department of Health and Human Services. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service. Financial support: A.E.S. was supported by a scholarship from FAPESP, São Paulo State Government. * Current address: Division of Gastroenterology, Escola Paulista de Medi-cina, São Paulo, Brazil. †Current address: Department of Medicine, St. Louis University Health Sciences Center, St. Louis. Reprints or correspondence: Dr. Brian J. McMahon, Arctic Investigations Program, Centers for Disease Control and Prevention, 4055 Tudor Centre Drive, Anchorage, Alaska 99508-5902.

PY - 1998

Y1 - 1998

N2 - Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

AB - Serum samples from 133 persons who were positive only for antibody to hepatitis B core antigen (anti-HBc) by enzyme immunoassay (EIA) were retested for seromarkers of hepatitis B virus (HBV) by radioimmunoassay and for HBV DNA by polymerase chain reaction analysis. All persons were subsequently vaccinated with hepatitis B vaccine. HBV DNA was found in only five persons, four of whom remained positive during retesting. Most persons had a primary antibody response with three doses of hepatitis B vaccine. Evidence of HBV DNA was not detected in 96% of persons with isolated anti-HBc by EIA.

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JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

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ER -

Hepatitis B virus DNA in persons with isolated antibody to hepatitis B core antigen who subsequently received hepatitis B vaccine

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