TY - JOUR
T1 - Hereditary Colorectal Cancer Syndromes and the Role of the Surgical Oncologist
AU - Learn, Peter A.
AU - Kahlenberg, Morton S.
PY - 2009/1
Y1 - 2009/1
N2 - The expanding understanding of the genetic basis to hereditary colon cancer syndromes is dismantling previously conceived categorizations and shedding light on why those schemes often failed in past. This review highlights evolving concepts regarding the genetic diagnosis and clinical management of the more commonly inherited colorectal cancer syndromes, including a discussion of recently described familial syndromes. This review also addresses clinician responsibilities in recognition of familial syndromes and provision of counseling.
AB - The expanding understanding of the genetic basis to hereditary colon cancer syndromes is dismantling previously conceived categorizations and shedding light on why those schemes often failed in past. This review highlights evolving concepts regarding the genetic diagnosis and clinical management of the more commonly inherited colorectal cancer syndromes, including a discussion of recently described familial syndromes. This review also addresses clinician responsibilities in recognition of familial syndromes and provision of counseling.
KW - Colorectal neoplasms
KW - Genetic testing
KW - Genetics
UR - http://www.scopus.com/inward/record.url?scp=57049137811&partnerID=8YFLogxK
U2 - 10.1016/j.soc.2008.08.007
DO - 10.1016/j.soc.2008.08.007
M3 - Review article
C2 - 19056045
AN - SCOPUS:57049137811
SN - 1055-3207
VL - 18
SP - 121
EP - 144
JO - Surgical Oncology Clinics of North America
JF - Surgical Oncology Clinics of North America
IS - 1
ER -