Heterogeneity in RAS mutations: One size does not fit all

Nancy E. Sealover; Robert L. Kortum

doi:10.1126/scisignal.adc9816

Heterogeneity in RAS mutations: One size does not fit all

Nancy E. Sealover, Robert L. Kortum^*

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh et al. show that even among KRAS^Q61 mutants, the specific amino acid that is substituted substantially affects mutant KRAS biologic activity and oncogenicity.

Original language	English
Article number	eadc9816
Journal	Science Signaling
Volume	15
Issue number	746
DOIs	https://doi.org/10.1126/scisignal.adc9816
State	Published - 9 Aug 2022

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title = "Heterogeneity in RAS mutations: One size does not fit all",

abstract = "Although oncogenic driver mutations in RAS occur in 20\% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh et al. show that even among KRASQ61 mutants, the specific amino acid that is substituted substantially affects mutant KRAS biologic activity and oncogenicity.",

author = "Sealover, \{Nancy E.\} and Kortum, \{Robert L.\}",

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AU - Kortum, Robert L.

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AB - Although oncogenic driver mutations in RAS occur in 20% of cancers, heterogeneity in the biologic outputs of different RAS mutants has hampered efforts to develop effective treatments for RAS-mutated cancers. In this issue of Science Signaling, Huynh et al. show that even among KRASQ61 mutants, the specific amino acid that is substituted substantially affects mutant KRAS biologic activity and oncogenicity.

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Heterogeneity in RAS mutations: One size does not fit all

Abstract

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