Heterotopic Ossification and Hypertrophic Scars

Shailesh Agarwal, Michael Sorkin, Benjamin Levi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


Burns and trauma cause superficial and deep soft tissue wounds that cannot heal to the preinjury state. Healing requires cell proliferation and differentiation into the injured tissue type, laying down extracellular matrix, often as collagens. Heterotopic ossification causes severe pain, nonhealing wounds, and restricted range of motion. Treatment includes radiation therapy, nonsteroidal anti-inflammatory drugs, bisphosphonates, and possibly surgical excision and prophylactic measures. Hypertrophic scars, nonosseous lesions caused by excessive collagen deposition, are often painful, functionally limiting, and aesthetically displeasing. Treatment includes CO2 laser application, steroid injections, and excision with skin grafting. This article reviews the management of these pathologic wounds.

Original languageEnglish
Pages (from-to)749-755
Number of pages7
JournalClinics in Plastic Surgery
Issue number4
StatePublished - Oct 2017
Externally publishedYes


  • Burn injury
  • Heterotopic ossification
  • Hypertrophic scar


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