Heterotopic ossification in orthopaedic trauma

Aaron Nauth, Erica Giles, Benjamin K. Potter, Leon J. Nesti, Frederick P. O'Brien, Michael J. Bosse, Jeffrey O. Anglen, Samir Mehta, Jaimo Ahn, Theodore Miclau, Emil H. Schemitsch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Heterotopic ossification (HO) can be defined as the pathologic formation of bone in extraskeletal tissues. There has been a substantial amount of recent research on the pathophysiology, prophylaxis, and treatment of HO and traumatic conditions associated with the development of HO. This research has advanced our understanding of this disease and helped to clarify evidence-based approaches to both the prophylaxis and treatment of HO. This article reviews the literature on these topics with a focus on their application in orthopaedic trauma.

Original languageEnglish
Pages (from-to)684-688
Number of pages5
JournalJournal of Orthopaedic Trauma
Volume26
Issue number12
DOIs
StatePublished - Dec 2012
Externally publishedYes

Keywords

  • NSAIDs
  • blast injuries
  • heterotopic ossification
  • pathophysiology
  • prophylaxis
  • radiation therapy
  • spinal cord injury
  • surgical treatment
  • traumatic brain injury

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