High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer

Ximena Leighton; Alakesh Bera; Ofer Eidelman; Michael Eklund; Narayanan Puthillathu; Harvey B. Pollard; Meera Srivastava

doi:10.21873/anticanres.12667

High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer

Ximena Leighton, Alakesh Bera, Ofer Eidelman, Michael Eklund, Narayanan Puthillathu, Harvey B. Pollard, Meera Srivastava^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Background/Aim: Our studies showed that ANXA7 is a novel tumor suppressor gene that is lost in various aggressive forms of prostate cancer. However, little is known about the role of ANXA7 in the anticancer drug treatment towards different cancers. Materials and Methods: The expression of ANXA7 was measured in the 60 cancer cell lines of the NCI-60 ADS project and correlated with the enhanced sensitivity to over 30,000 natural and synthetic compounds. Results: Eucalyptol showed a high positive correlation with ANXA7 expression and castration-resistant prostate cancer cell death occurred very effectively in response to the combination of eucalyptol and overexpressed wt-ANXA7 than either agent alone. The synergistic effects of ANXA7 and eucalyptol resulted in concordant changes in gene expression profiles particularly of Ras family members, MDM4, NF-ĸB and VEGF. Conclusion: Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines.

Original language	English
Pages (from-to)	3831-3842
Number of pages	12
Journal	Anticancer Research
Volume	38
Issue number	7
DOIs	https://doi.org/10.21873/anticanres.12667
State	Published - Jul 2018
Externally published	Yes

Keywords

ANXA7
Anticancer Drug Screen (NCI-60 ADS)
Chemo-sensitivity
Eucalyptol
National Cancer Institute - 60 cancer cell line screening (NCI-60)
Prostate cancer

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title = "High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer",

abstract = "Background/Aim: Our studies showed that ANXA7 is a novel tumor suppressor gene that is lost in various aggressive forms of prostate cancer. However, little is known about the role of ANXA7 in the anticancer drug treatment towards different cancers. Materials and Methods: The expression of ANXA7 was measured in the 60 cancer cell lines of the NCI-60 ADS project and correlated with the enhanced sensitivity to over 30,000 natural and synthetic compounds. Results: Eucalyptol showed a high positive correlation with ANXA7 expression and castration-resistant prostate cancer cell death occurred very effectively in response to the combination of eucalyptol and overexpressed wt-ANXA7 than either agent alone. The synergistic effects of ANXA7 and eucalyptol resulted in concordant changes in gene expression profiles particularly of Ras family members, MDM4, NF-ĸB and VEGF. Conclusion: Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines.",

keywords = "ANXA7, Anticancer Drug Screen (NCI-60 ADS), Chemo-sensitivity, Eucalyptol, National Cancer Institute - 60 cancer cell line screening (NCI-60), Prostate cancer",

author = "Ximena Leighton and Alakesh Bera and Ofer Eidelman and Michael Eklund and Narayanan Puthillathu and Pollard, {Harvey B.} and Meera Srivastava",

year = "2018",

month = jul,

doi = "10.21873/anticanres.12667",

language = "English",

volume = "38",

pages = "3831--3842",

journal = "Anticancer Research",

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T1 - High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer

AU - Leighton, Ximena

AU - Bera, Alakesh

AU - Eidelman, Ofer

AU - Eklund, Michael

AU - Puthillathu, Narayanan

AU - Pollard, Harvey B.

AU - Srivastava, Meera

PY - 2018/7

Y1 - 2018/7

N2 - Background/Aim: Our studies showed that ANXA7 is a novel tumor suppressor gene that is lost in various aggressive forms of prostate cancer. However, little is known about the role of ANXA7 in the anticancer drug treatment towards different cancers. Materials and Methods: The expression of ANXA7 was measured in the 60 cancer cell lines of the NCI-60 ADS project and correlated with the enhanced sensitivity to over 30,000 natural and synthetic compounds. Results: Eucalyptol showed a high positive correlation with ANXA7 expression and castration-resistant prostate cancer cell death occurred very effectively in response to the combination of eucalyptol and overexpressed wt-ANXA7 than either agent alone. The synergistic effects of ANXA7 and eucalyptol resulted in concordant changes in gene expression profiles particularly of Ras family members, MDM4, NF-ĸB and VEGF. Conclusion: Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines.

AB - Background/Aim: Our studies showed that ANXA7 is a novel tumor suppressor gene that is lost in various aggressive forms of prostate cancer. However, little is known about the role of ANXA7 in the anticancer drug treatment towards different cancers. Materials and Methods: The expression of ANXA7 was measured in the 60 cancer cell lines of the NCI-60 ADS project and correlated with the enhanced sensitivity to over 30,000 natural and synthetic compounds. Results: Eucalyptol showed a high positive correlation with ANXA7 expression and castration-resistant prostate cancer cell death occurred very effectively in response to the combination of eucalyptol and overexpressed wt-ANXA7 than either agent alone. The synergistic effects of ANXA7 and eucalyptol resulted in concordant changes in gene expression profiles particularly of Ras family members, MDM4, NF-ĸB and VEGF. Conclusion: Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines.

KW - ANXA7

KW - Anticancer Drug Screen (NCI-60 ADS)

KW - Chemo-sensitivity

KW - Eucalyptol

KW - National Cancer Institute - 60 cancer cell line screening (NCI-60)

KW - Prostate cancer

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U2 - 10.21873/anticanres.12667

DO - 10.21873/anticanres.12667

M3 - Article

C2 - 29970503

AN - SCOPUS:85049790538

SN - 0250-7005

VL - 38

SP - 3831

EP - 3842

JO - Anticancer Research

JF - Anticancer Research

IS - 7

ER -

High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer

Abstract

Keywords

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