High ANXA7 potentiates eucalyptol toxicity in hormone-refractory prostate cancer

Ximena Leighton, Alakesh Bera, Ofer Eidelman, Michael Eklund, Narayanan Puthillathu, Harvey B. Pollard, Meera Srivastava*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background/Aim: Our studies showed that ANXA7 is a novel tumor suppressor gene that is lost in various aggressive forms of prostate cancer. However, little is known about the role of ANXA7 in the anticancer drug treatment towards different cancers. Materials and Methods: The expression of ANXA7 was measured in the 60 cancer cell lines of the NCI-60 ADS project and correlated with the enhanced sensitivity to over 30,000 natural and synthetic compounds. Results: Eucalyptol showed a high positive correlation with ANXA7 expression and castration-resistant prostate cancer cell death occurred very effectively in response to the combination of eucalyptol and overexpressed wt-ANXA7 than either agent alone. The synergistic effects of ANXA7 and eucalyptol resulted in concordant changes in gene expression profiles particularly of Ras family members, MDM4, NF-ĸB and VEGF. Conclusion: Overexpression of ANXA7 enhances eucalyptol cytotoxicity in prostate cancer cell lines.

Original languageEnglish
Pages (from-to)3831-3842
Number of pages12
JournalAnticancer Research
Issue number7
StatePublished - Jul 2018
Externally publishedYes


  • ANXA7
  • Anticancer Drug Screen (NCI-60 ADS)
  • Chemo-sensitivity
  • Eucalyptol
  • National Cancer Institute - 60 cancer cell line screening (NCI-60)
  • Prostate cancer


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