High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

Ke Zhang, Jin Yan, Bo Yi, Yuanyi Rui, Hai Hu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18-3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54-5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.

Original languageEnglish
Pages (from-to)1085-1095
Number of pages11
JournalFuture Oncology
Issue number10
StatePublished - Apr 2019
Externally publishedYes


  • KCNQ1OT1
  • colon adenocarcinoma
  • prognosis
  • rectal adenocarcinoma


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