High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

Ke Zhang; Jin Yan; Bo Yi; Yuanyi Rui; Hai Hu

doi:10.2217/fon-2018-0499

High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

Ke Zhang, Jin Yan, Bo Yi, Yuanyi Rui, Hai Hu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18-3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54-5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.

Original language	English
Pages (from-to)	1085-1095
Number of pages	11
Journal	Future Oncology
Volume	15
Issue number	10
DOIs	https://doi.org/10.2217/fon-2018-0499
State	Published - Apr 2019
Externally published	Yes

Keywords

KCNQ1OT1
colon adenocarcinoma
prognosis
rectal adenocarcinoma

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title = "High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma",

abstract = "Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18-3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54-5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.",

keywords = "KCNQ1OT1, colon adenocarcinoma, prognosis, rectal adenocarcinoma",

author = "Ke Zhang and Jin Yan and Bo Yi and Yuanyi Rui and Hai Hu",

note = "Publisher Copyright: {\textcopyright} 2019 2019 Future Medicine Ltd.",

year = "2019",

month = apr,

doi = "10.2217/fon-2018-0499",

language = "English",

volume = "15",

pages = "1085--1095",

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TY - JOUR

T1 - High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

AU - Zhang, Ke

AU - Yan, Jin

AU - Yi, Bo

AU - Rui, Yuanyi

AU - Hu, Hai

PY - 2019/4

Y1 - 2019/4

N2 - Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18-3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54-5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.

AB - Aim: To explore the expression profile of KCNQ1OT1 and its prognostic value in colon and rectal adenocarcinoma (COAD and READ) separately. Patients & methods: clinicopathological, genomic and survival data from The Cancer Genome Atlas and GSE39582 were obtained for a secondary analysis. Results: KCNQ1OT1 was significantly up-regulated in both COAD and READ compared with adjacent normal tissues. However, its up-regulation was only independently associated with shorter overall survival (hazard ratio: 2.02; 95% CI: 1.18-3.46; p = 0.01) and recurrence-free survival (hazard ratio: 2.79, 95% CI: 1.54-5.07; p < 0.01) in COAD, but not in READ. Conclusion: KCNQ1OT1 up-regulation might serve as a valuable independent prognostic indicator of shorter overall survival and recurrence-free survival of COAD, but not READ.

KW - KCNQ1OT1

KW - colon adenocarcinoma

KW - prognosis

KW - rectal adenocarcinoma

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SP - 1085

EP - 1095

JO - Future Oncology

JF - Future Oncology

IS - 10

ER -

High KCNQ1OT1 expression might independently predict shorter survival of colon adenocarcinoma

Abstract

Keywords

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