TY - JOUR
T1 - High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men
AU - Ananworanich, Jintanat
AU - Sirivichayakul, Sunee
AU - Pinyakorn, Suteeraporn
AU - Crowell, Trevor A.
AU - Trichavaroj, Rapee
AU - Weerayingyong, Jessica
AU - Chomchey, Nitiya
AU - Fletcher, James L.K.
AU - Van Griensven, Frits
AU - Phanuphak, Praphan
AU - Robb, Merlin L.
AU - Michael, Nelson L.
AU - Kim, Jerome H.
AU - Phanuphak, Nittaya
N1 - Publisher Copyright:
© 2014 Wolters Kluwer Health, Inc.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.
AB - As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.
KW - Thailand
KW - acute HIV
KW - men who have sex with men
KW - transmitted drug resistance
UR - http://www.scopus.com/inward/record.url?scp=84924487937&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000000502
DO - 10.1097/QAI.0000000000000502
M3 - Article
C2 - 25559593
AN - SCOPUS:84924487937
SN - 1525-4135
VL - 68
SP - 481
EP - 485
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 4
ER -