High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men

Jintanat Ananworanich; Sunee Sirivichayakul; Suteeraporn Pinyakorn; Trevor A. Crowell; Rapee Trichavaroj; Jessica Weerayingyong; Nitiya Chomchey; James L.K. Fletcher; Frits Van Griensven; Praphan Phanuphak; Merlin Robb; Nelson L. Michael; Jerome H. Kim; Nittaya Phanuphak

doi:10.1097/QAI.0000000000000502

High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men

Jintanat Ananworanich^*, Sunee Sirivichayakul, Suteeraporn Pinyakorn, Trevor A. Crowell, Rapee Trichavaroj, Jessica Weerayingyong, Nitiya Chomchey, James L.K. Fletcher, Frits Van Griensven, Praphan Phanuphak, Merlin Robb, Nelson L. Michael, Jerome H. Kim, Nittaya Phanuphak

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.

Original language	English
Pages (from-to)	481-485
Number of pages	5
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	68
Issue number	4
DOIs	https://doi.org/10.1097/QAI.0000000000000502
State	Published - 1 Apr 2015

Keywords

Thailand
acute HIV
men who have sex with men
transmitted drug resistance

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10.1097/QAI.0000000000000502

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Ananworanich, J., Sirivichayakul, S., Pinyakorn, S., Crowell, T. A., Trichavaroj, R., Weerayingyong, J., Chomchey, N., Fletcher, J. L. K., Van Griensven, F., Phanuphak, P., Robb, M., Michael, N. L., Kim, J. H., & Phanuphak, N. (2015). High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men. Journal of Acquired Immune Deficiency Syndromes, 68(4), 481-485. https://doi.org/10.1097/QAI.0000000000000502

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title = "High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men",

abstract = "As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.",

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author = "Jintanat Ananworanich and Sunee Sirivichayakul and Suteeraporn Pinyakorn and Crowell, {Trevor A.} and Rapee Trichavaroj and Jessica Weerayingyong and Nitiya Chomchey and Fletcher, {James L.K.} and {Van Griensven}, Frits and Praphan Phanuphak and Merlin Robb and Michael, {Nelson L.} and Kim, {Jerome H.} and Nittaya Phanuphak",

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Ananworanich, J, Sirivichayakul, S, Pinyakorn, S, Crowell, TA, Trichavaroj, R, Weerayingyong, J, Chomchey, N, Fletcher, JLK, Van Griensven, F, Phanuphak, P, Robb, M , Michael, NL, Kim, JH & Phanuphak, N 2015, 'High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men', Journal of Acquired Immune Deficiency Syndromes, vol. 68, no. 4, pp. 481-485. https://doi.org/10.1097/QAI.0000000000000502

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T1 - High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men

AU - Ananworanich, Jintanat

AU - Sirivichayakul, Sunee

AU - Pinyakorn, Suteeraporn

AU - Crowell, Trevor A.

AU - Trichavaroj, Rapee

AU - Weerayingyong, Jessica

AU - Chomchey, Nitiya

AU - Fletcher, James L.K.

AU - Van Griensven, Frits

AU - Phanuphak, Praphan

AU - Robb, Merlin

AU - Michael, Nelson L.

AU - Kim, Jerome H.

AU - Phanuphak, Nittaya

PY - 2015/4/1

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N2 - As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.

AB - As use of antiretroviral therapy in Thailand increases, so does the potential for transmission of drug-resistant HIV. We describe the prevalence of WHO surveillance drug resistance mutations among 120 subjects who underwent genotypic testing during acute HIV infection in Bangkok, Thailand. In this cohort of predominantly men who have sex with men, we observed an overall transmitted drug resistance prevalence of 9.2%, including nucleoside/nucleotide analog reverse transcriptase inhibitor 5.0%, nonnucleoside analog reverse transcriptase inhibitor 3.4%, and protease inhibitor 3.4%. These prevalence estimates are higher than previous reports of transmitted drug resistance in Thailand. Baseline drug resistance testing may be warranted, particularly among men who have sex with men.

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High prevalence of transmitted drug resistance in acute HIV-infected thai men who have sex with men

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