High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials

Thuvan Piehler; Nicole Zander; Rohan Banton; Richard Benjamin; Ray Sparks; Kimberly Byrnes; Josh Duckworth; Ben A. Bahr

doi:10.1007/978-3-319-62956-8_21

High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials

Thuvan Piehler^*, Nicole Zander, Rohan Banton, Richard Benjamin, Ray Sparks, Kimberly Byrnes, Josh Duckworth, Ben A. Bahr

^*Corresponding author for this work

Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Scopus citations

Abstract

Threshold shock-impulse levels required to induce cellular injury and cumulative effects upon single and/or multiple exposures are not well-characterized. There are very few in vitro experimental model with blast pressure waves generated by using explosives in the laboratory for investigating the effects of primary blast induced traumatic brain injury. Hence, it is critical to develop a reliable experimental research tool in the laboratory to study how functional and structural alteration or damage at the cellular and tissue levels following explosive blast impacts for future improvement of detection and subsequent treatment and protection. US Army Research Laboratory (ARL) developed the unique in vitro indoor experimental platform that uses military explosive charges to accurately represent battle-field blast exposure and to probe the effects of primary explosive blast on dissociated neurons and tissue slices. We believe this is one of the controlled experimental methods to analyze, characterize primary explosive blast induced cellular injury, and understand threshold injury phenomenon.

Original language	English
Title of host publication	Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics
Editors	Leslie Lamberson, Steven Mates, Jamie Kimberley
Publisher	Springer New York LLC
Pages	123-126
Number of pages	4
ISBN (Print)	9783319629551
DOIs	https://doi.org/10.1007/978-3-319-62956-8_21
State	Published - 2018
Event	Annual Conference and Exposition on Experimental and Applied Mechanics, 2017 - Indianapolis, United States Duration: 12 Jun 2017 → 15 Jun 2017

Publication series

Name	Conference Proceedings of the Society for Experimental Mechanics Series
Volume	1
ISSN (Print)	2191-5644
ISSN (Electronic)	2191-5652

Conference

Conference	Annual Conference and Exposition on Experimental and Applied Mechanics, 2017
Country/Territory	United States
City	Indianapolis
Period	12/06/17 → 15/06/17

Keywords

Explosive charges
High speed imaging
Neurons
Pressure waves
Tissues

Access to Document

10.1007/978-3-319-62956-8_21

Cite this

Piehler, T., Zander, N., Banton, R., Benjamin, R., Sparks, R., Byrnes, K., Duckworth, J., & Bahr, B. A. (2018). High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. In L. Lamberson, S. Mates, & J. Kimberley (Eds.), Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics (pp. 123-126). (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 1). Springer New York LLC. https://doi.org/10.1007/978-3-319-62956-8_21

Piehler, Thuvan ; Zander, Nicole ; Banton, Rohan et al. / High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. editor / Leslie Lamberson ; Steven Mates ; Jamie Kimberley. Springer New York LLC, 2018. pp. 123-126 (Conference Proceedings of the Society for Experimental Mechanics Series).

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title = "High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials",

abstract = "Threshold shock-impulse levels required to induce cellular injury and cumulative effects upon single and/or multiple exposures are not well-characterized. There are very few in vitro experimental model with blast pressure waves generated by using explosives in the laboratory for investigating the effects of primary blast induced traumatic brain injury. Hence, it is critical to develop a reliable experimental research tool in the laboratory to study how functional and structural alteration or damage at the cellular and tissue levels following explosive blast impacts for future improvement of detection and subsequent treatment and protection. US Army Research Laboratory (ARL) developed the unique in vitro indoor experimental platform that uses military explosive charges to accurately represent battle-field blast exposure and to probe the effects of primary explosive blast on dissociated neurons and tissue slices. We believe this is one of the controlled experimental methods to analyze, characterize primary explosive blast induced cellular injury, and understand threshold injury phenomenon.",

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author = "Thuvan Piehler and Nicole Zander and Rohan Banton and Richard Benjamin and Ray Sparks and Kimberly Byrnes and Josh Duckworth and Bahr, {Ben A.}",

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Piehler, T, Zander, N, Banton, R, Benjamin, R, Sparks, R, Byrnes, K, Duckworth, J & Bahr, BA 2018, High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. in L Lamberson, S Mates & J Kimberley (eds), Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. Conference Proceedings of the Society for Experimental Mechanics Series, vol. 1, Springer New York LLC, pp. 123-126, Annual Conference and Exposition on Experimental and Applied Mechanics, 2017, Indianapolis, United States, 12/06/17. https://doi.org/10.1007/978-3-319-62956-8_21

High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. / Piehler, Thuvan; Zander, Nicole; Banton, Rohan et al.
Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. ed. / Leslie Lamberson; Steven Mates; Jamie Kimberley. Springer New York LLC, 2018. p. 123-126 (Conference Proceedings of the Society for Experimental Mechanics Series; Vol. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Threshold shock-impulse levels required to induce cellular injury and cumulative effects upon single and/or multiple exposures are not well-characterized. There are very few in vitro experimental model with blast pressure waves generated by using explosives in the laboratory for investigating the effects of primary blast induced traumatic brain injury. Hence, it is critical to develop a reliable experimental research tool in the laboratory to study how functional and structural alteration or damage at the cellular and tissue levels following explosive blast impacts for future improvement of detection and subsequent treatment and protection. US Army Research Laboratory (ARL) developed the unique in vitro indoor experimental platform that uses military explosive charges to accurately represent battle-field blast exposure and to probe the effects of primary explosive blast on dissociated neurons and tissue slices. We believe this is one of the controlled experimental methods to analyze, characterize primary explosive blast induced cellular injury, and understand threshold injury phenomenon.

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Piehler T, Zander N, Banton R, Benjamin R, Sparks R, Byrnes K et al. High speed imaging techniques to study effects of pressure waves from detonating explosive charges on biological materials. In Lamberson L, Mates S, Kimberley J, editors, Dynamic Behavior of Materials - Proceedings of the 2017 Annual Conference on Experimental and Applied Mechanics. Springer New York LLC. 2018. p. 123-126. (Conference Proceedings of the Society for Experimental Mechanics Series). doi: 10.1007/978-3-319-62956-8_21