The Duke Advanced Vitreous Surgery (AVS) Course, initiated by Robert Machemer, MD, boasts a series of excellent lectures and interactive panel discussions with vitreoretinal surgery leaders from all over the world. It takes place every other year in Durham, North Carolina, and is open to all retina specialists. The course places an emphasis on a diverse range of vitreoretinal surgery and medical retina topics, including retinal detachment, novel drugs and devices, trainee presentations, management of intra-ocular tumors and uveitis, and pediatric retina. Furthermore, the course takes pride in the international diversity of its panel members, this year with faculty from Singapore, Poland, Canada, Brazil, and Croatia. Here, we share key highlights from the meeting, including an update on treatments for retinal vein occlusion (RVO) and intraoperative OCT (iOCT).