HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders

Holly Janes, Joshua T. Herbeck, Sodsai Tovanabutra, Rasmi Thomas, Nicole Frahm, Ann Duerr, John Hural, Lawrence Corey, Steve G. Self, Susan P. Buchbinder, M. Juliana McElrath, Robert J. O'Connell, Robert M. Paris, Supachai Rerks-Ngarm, Sorachai Nitayaphan, Punnee Pitisuttihum, Jaranit Kaewkungwal, Merlin L. Robb, Nelson L. Michael, James I. MullinsJerome H. Kim, Peter B. Gilbert, Morgane Rolland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.

Original languageEnglish
Pages (from-to)1139-1141
Number of pages3
JournalNature Medicine
Volume21
Issue number10
DOIs
StatePublished - 1 Oct 2015
Externally publishedYes

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