TY - JOUR
T1 - HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders
AU - Janes, Holly
AU - Herbeck, Joshua T.
AU - Tovanabutra, Sodsai
AU - Thomas, Rasmi
AU - Frahm, Nicole
AU - Duerr, Ann
AU - Hural, John
AU - Corey, Lawrence
AU - Self, Steve G.
AU - Buchbinder, Susan P.
AU - McElrath, M. Juliana
AU - O'Connell, Robert J.
AU - Paris, Robert M.
AU - Rerks-Ngarm, Supachai
AU - Nitayaphan, Sorachai
AU - Pitisuttihum, Punnee
AU - Kaewkungwal, Jaranit
AU - Robb, Merlin L.
AU - Michael, Nelson L.
AU - Mullins, James I.
AU - Kim, Jerome H.
AU - Gilbert, Peter B.
AU - Rolland, Morgane
N1 - Publisher Copyright:
© 2015 Nature America, Inc. All rights reserved.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
AB - Given the variation in the HIV-1 viral load (VL) set point across subjects, as opposed to a fairly stable VL over time within an infected individual, it is important to identify the characteristics of the host and virus that affect VL set point. Although recently infected individuals with multiple phylogenetically linked HIV-1 founder variants represent a minority of HIV-1 infections, we found - in two different cohorts - that more diverse HIV-1 populations in early infection were associated with significantly higher VL 1 year after HIV-1 diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=84943663211&partnerID=8YFLogxK
U2 - 10.1038/nm.3932
DO - 10.1038/nm.3932
M3 - Article
C2 - 26322580
AN - SCOPUS:84943663211
SN - 1078-8956
VL - 21
SP - 1139
EP - 1141
JO - Nature Medicine
JF - Nature Medicine
IS - 10
ER -