HIV and SARS-CoV-2: Tracing a Path of Vaccine Research and Development

Brittany Ober Shepherd, David Chang, Sandhya Vasan, Julie Ake, Kayvon Modjarrad*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Purpose of Review: This review examines the major advances and obstacles in the field of HIV vaccine research as they pertain to informing the development of vaccines against SARS-CoV-2. Recent Findings: Although the field of HIV research has yet to deliver a licensed vaccine, the technologies developed and knowledge gained in basic scientific disciplines, translational research, and community engagement have positively impacted the development of vaccines for other viruses, most notably and recently for SARS-CoV-2. These advances include the advent of viral vectors and mRNA as vaccine delivery platforms; the use of structural biology for immunogen design; an emergence of novel adjuvant formulations; a more sophisticated understanding of viral phylogenetics; improvements in the development and harmonization of accurate assays for vaccine immunogenicity; and maturation of the fields of bioethics and community engagement for clinical trials conducted in diverse populations. Summary: Decades of foundational research and investments into HIV biology, though yet to yield an authorized or approved vaccine for HIV/AIDS, have now paid dividends in the rapid development of safe and effective SARS-CoV-2 vaccines. This latter success presents an opportunity for feedback on improved pathways for development of safe and efficacious vaccines against HIV and other pathogens.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalCurrent HIV/AIDS Reports
Issue number1
StatePublished - Feb 2022
Externally publishedYes


  • HIV
  • Lessons
  • Research
  • SARS-COV-2
  • Vaccine


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