TY - JOUR
T1 - HIV outcomes in hepatitis B virus coinfected individuals on HAART
AU - Chun, Helen M.
AU - Mesner, Octavio
AU - Thio, Chloe L.
AU - Bebu, Ionut
AU - Macalino, Grace
AU - Agan, Brian K.
AU - Bradley, William P.
AU - Malia, Jennifer
AU - Peel, Sheila A.
AU - Jagodzinski, Linda L.
AU - Weintrob, Amy C.
AU - Ganesan, Anuradha
AU - Bavaro, Mary
AU - Maguire, Jason D.
AU - Landrum, Michael L.
PY - 2014/6/1
Y1 - 2014/6/1
N2 - Background: Understanding the impact of hepatitis B virus (HBV) coinfection on HIV outcomes in the highly active antiretroviral therapy (HAART) era continues to be a critical priority given the high prevalence of coinfection and the potential for impaired immunologic, virologic, and clinical recovery. Methods: Participants from the US Military HIV Natural History Study with an HIV diagnosis on HAART and serologically confirmed HBV infection status at HAART initiation (HI) were classified into 4 HBV infection (HB) groups. HIV virologic, immunologic, and clinical outcomes were evaluated by HB status. Results: Of 2536 HIV-positive HAART recipients, with HBV testing results available to determine HB status in the HI window, HB status at HI was classified as HB negative (n = 1505; 66%), resolved HB (n = 518; 23%), isolated hepatitis B core antigen (n = 139; 6%), or chronic HB (n = 131; 6%). HIV virologic suppression and failure at 6 months or 1 year were not significantly different by HB status. A significantly faster rate of increase in CD4 cell count during the period between 4 and 12 years was observed for chronic HB relative to HB negative. Chronic and resolved HB were associated with an increased risk of AIDS/death compared with HB-negative individuals (chronic HB - hazard ratio = 1.68, 95% confidence interval: 1.05 to 2.68; resolved HB - hazard ratio = 1.61, 95% confidence interval: 1.15 to 2.25). Conclusions: HB status did not have a significant impact on HIV virologic outcomes, however, CD4 cell count reconstitution after HI and the risk of an AIDS event or death after HI may be associated with HB status.
AB - Background: Understanding the impact of hepatitis B virus (HBV) coinfection on HIV outcomes in the highly active antiretroviral therapy (HAART) era continues to be a critical priority given the high prevalence of coinfection and the potential for impaired immunologic, virologic, and clinical recovery. Methods: Participants from the US Military HIV Natural History Study with an HIV diagnosis on HAART and serologically confirmed HBV infection status at HAART initiation (HI) were classified into 4 HBV infection (HB) groups. HIV virologic, immunologic, and clinical outcomes were evaluated by HB status. Results: Of 2536 HIV-positive HAART recipients, with HBV testing results available to determine HB status in the HI window, HB status at HI was classified as HB negative (n = 1505; 66%), resolved HB (n = 518; 23%), isolated hepatitis B core antigen (n = 139; 6%), or chronic HB (n = 131; 6%). HIV virologic suppression and failure at 6 months or 1 year were not significantly different by HB status. A significantly faster rate of increase in CD4 cell count during the period between 4 and 12 years was observed for chronic HB relative to HB negative. Chronic and resolved HB were associated with an increased risk of AIDS/death compared with HB-negative individuals (chronic HB - hazard ratio = 1.68, 95% confidence interval: 1.05 to 2.68; resolved HB - hazard ratio = 1.61, 95% confidence interval: 1.15 to 2.25). Conclusions: HB status did not have a significant impact on HIV virologic outcomes, however, CD4 cell count reconstitution after HI and the risk of an AIDS event or death after HI may be associated with HB status.
KW - HIV
KW - chronic hepatitis B
KW - hepatitis B virus
KW - highly active antiretroviral therapy
UR - http://www.scopus.com/inward/record.url?scp=84901491483&partnerID=8YFLogxK
U2 - 10.1097/QAI.0000000000000142
DO - 10.1097/QAI.0000000000000142
M3 - Article
C2 - 24694929
AN - SCOPUS:84901491483
SN - 1525-4135
VL - 66
SP - 197
EP - 205
JO - Journal of Acquired Immune Deficiency Syndromes
JF - Journal of Acquired Immune Deficiency Syndromes
IS - 2
ER -