HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster

G. H. Kijak; A. M. Walsh; R. N. Koehler; N. Moqueet; L. A. Eller; M. Eller; J. R. Currier; Z. Wang; F. Wabwire-Mangen; H. N. Kibuuka; N. L. Michael; M. L. Robb; F. E. McCutchan

doi:10.1111/j.1399-0039.2008.01192.x

HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster

G. H. Kijak, A. M. Walsh, R. N. Koehler, N. Moqueet, L. A. Eller, M. Eller, J. R. Currier, Z. Wang, F. Wabwire-Mangen, H. N. Kibuuka, N. L. Michael, M. L. Robb, F. E. McCutchan

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30 Scopus citations

Abstract

: The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines.

Original language	English
Pages (from-to)	262-269
Number of pages	8
Journal	Tissue Antigens
Volume	73
Issue number	3
DOIs	https://doi.org/10.1111/j.1399-0039.2008.01192.x
State	Published - Mar 2009
Externally published	Yes

Keywords

East Africa
Genetic distance
HLA class I genes
Haplotype frequency
Uganda

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10.1111/j.1399-0039.2008.01192.x

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Kijak, G. H., Walsh, A. M., Koehler, R. N., Moqueet, N., Eller, L. A., Eller, M., Currier, J. R., Wang, Z., Wabwire-Mangen, F., Kibuuka, H. N., Michael, N. L., Robb, M. L., & McCutchan, F. E. (2009). HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster. Tissue Antigens, 73(3), 262-269. https://doi.org/10.1111/j.1399-0039.2008.01192.x

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title = "HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster",

abstract = ": The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines.",

keywords = "East Africa, Genetic distance, HLA class I genes, Haplotype frequency, Uganda",

author = "Kijak, {G. H.} and Walsh, {A. M.} and Koehler, {R. N.} and N. Moqueet and Eller, {L. A.} and M. Eller and Currier, {J. R.} and Z. Wang and F. Wabwire-Mangen and Kibuuka, {H. N.} and Michael, {N. L.} and Robb, {M. L.} and McCutchan, {F. E.}",

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Kijak, GH, Walsh, AM, Koehler, RN, Moqueet, N, Eller, LA, Eller, M, Currier, JR, Wang, Z, Wabwire-Mangen, F, Kibuuka, HN, Michael, NL, Robb, ML & McCutchan, FE 2009, 'HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster', Tissue Antigens, vol. 73, no. 3, pp. 262-269. https://doi.org/10.1111/j.1399-0039.2008.01192.x

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T1 - HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster

AU - Kijak, G. H.

AU - Walsh, A. M.

AU - Koehler, R. N.

AU - Moqueet, N.

AU - Eller, L. A.

AU - Eller, M.

AU - Currier, J. R.

AU - Wang, Z.

AU - Wabwire-Mangen, F.

AU - Kibuuka, H. N.

AU - Michael, N. L.

AU - Robb, M. L.

AU - McCutchan, F. E.

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N2 - : The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines.

AB - : The objective of this study was to characterize the class I human leukocyte antigen (HLA) genetic composition of the Ugandan population to better define its relationship with other African groups. Samples from 175 individuals from Kampala (Uganda) were subjected to class I HLA-A, -B, and -C sequence-based typing. The high concordance between the major alleles and haplotypes found in the current and Kenyan populations and interpopulation genetic distance analysis strongly supported the presence of an East African cluster that contained the current Ugandan population along with Kenyan Luo and Nandi populations. The congruence of major alleles in different populations would permit consideration of East Africa as an integrated setting when designing and evaluating much needed malaria, tuberculosis, and AIDS vaccines.

KW - East Africa

KW - Genetic distance

KW - HLA class I genes

KW - Haplotype frequency

KW - Uganda

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ER -

HLA class i allele and haplotype diversity in Ugandans supports the presence of a major east African genetic cluster

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Keywords

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