HLA-DR, HLA-DQ, and TAP genes in familial Hodgkin disease

Lea C. Harty, Albert Y. Lin, Alisa M. Goldstein*, Elaine S. Jaffe, Mary Carrington, Margaret A. Tucker, William S. Modi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


The HLA region has long been implicated in sporadic and familial Hodgkin disease (HD), with recent case-control studies suggesting that HLA class II loci predispose to sporadic nodular sclerosis HD (NSHD). To determine whether this predisposition extends to familial HD, HLA class II loci (DRB1, DQA1, DQB1, DRB3, DRB4, and DRB5) and transporter associated with antigen processing (TAP) loci (TAP1, TAP2) were investigated in 100 members of 16 families with at least 2 confirmed cases of HD. With the use of the transmission disequilibrium test, evidence for linkage disequilibrium with familial HD and, in particular, familial NSHD was obtained for the DR DRB1*1501-DQA1*0102-DQB1*0602 haplotype, the TAP1 allele encoding lle at residue 333, and the DRB5-0101 allele. These 3 markers were in linkage disequilibrium and may not represent independent susceptibility regions. Use of a family-based approach excludes population stratification as an explanation for these findings.

Original languageEnglish
Pages (from-to)690-693
Number of pages4
Issue number2
StatePublished - 15 Jan 2002


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