HMGB1 preconditioning: Therapeutic application for a danger signal?

J. R. Klune, T. R. Billiar, A. Tsung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


High mobility group box 1 (HMGB1) is a nuclear factor released extracellularly as a late mediator of lethality in sepsis and as an early mediator of inflammation following injury. In contrast to the proinflammatory role of HMGB1, recent evidence suggests beneficial applications of HMGB1 in injury states. One such application is the use of HMGB1 as a preconditioning stimulus. Preconditioning is a phenomenon whereby a low level of stressful stimuli confers protection against subsequent injury. Preconditioning has been demonstrated in multiple species, can be induced by various stimuli, and is applicable in different organ systems. Only with the recent introduction of the concept of endogenous molecules, such as HMGB1, as signals and mediators for inflammation during injury states has the use of endogenous molecules been investigated for this use. This review will focus on the use of endogenous molecules, specifically HMGB1, as a preconditioning stimulus and its mechanism of protection, as well as other protective applications for HMGB1.

Original languageEnglish
Pages (from-to)558-563
Number of pages6
JournalJournal of Leukocyte Biology
Issue number3
StatePublished - 1 Mar 2008
Externally publishedYes


  • Endogenous danger molecules
  • Endotoxin
  • Ischemia/reperfusion
  • Toll-like receptor


Dive into the research topics of 'HMGB1 preconditioning: Therapeutic application for a danger signal?'. Together they form a unique fingerprint.

Cite this