Homeostasis of αβ TCR+ T cells

Philippa Marrack; Jeremy Bender; David Hildeman; Michael Jordan; Tom Mitchell; Masaaki Murakami; Akemi Sakamoto; Brian C. Schaefer; Bradley Swanson; John Kappler

doi:10.1038/77778

Homeostasis of αβ TCR⁺ T cells

Philippa Marrack^*, Jeremy Bender, David Hildeman, Michael Jordan, Tom Mitchell, Masaaki Murakami, Akemi Sakamoto, Brian C. Schaefer, Bradley Swanson, John Kappler

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

229 Scopus citations

Abstract

Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	Nature Immunology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1038/77778
State	Published - Aug 2000
Externally published	Yes

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10.1038/77778

Cite this

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title = "Homeostasis of αβ TCR+ T cells",

abstract = "Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a na{\"i}ve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.",

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AU - Hildeman, David

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AU - Murakami, Masaaki

AU - Sakamoto, Akemi

AU - Schaefer, Brian C.

AU - Swanson, Bradley

AU - Kappler, John

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AB - Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

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