Homeostasis of αβ TCR+ T cells

Philippa Marrack; Jeremy Bender; David Hildeman; Michael Jordan; Tom Mitchell; Masaaki Murakami; Akemi Sakamoto; Brian C. Schaefer; Bradley Swanson; John Kappler

doi:10.1038/77778

Homeostasis of αβ TCR⁺ T cells

Philippa Marrack^*
, Jeremy Bender
, David Hildeman
, Michael Jordan
, Tom Mitchell
, Masaaki Murakami
, Akemi Sakamoto
, Brian C. Schaefer
, Bradley Swanson
, John Kappler

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

229 Scopus citations

Abstract

Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

Original language	English
Pages (from-to)	107-111
Number of pages	5
Journal	Nature Immunology
Volume	1
Issue number	2
DOIs	https://doi.org/10.1038/77778
State	Published - Aug 2000
Externally published	Yes

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10.1038/77778

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title = "Homeostasis of αβ TCR+ T cells",

abstract = "Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a na{\"i}ve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.",

author = "Philippa Marrack and Jeremy Bender and David Hildeman and Michael Jordan and Tom Mitchell and Masaaki Murakami and Akemi Sakamoto and Schaefer, \{Brian C.\} and Bradley Swanson and John Kappler",

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AU - Marrack, Philippa

AU - Bender, Jeremy

AU - Hildeman, David

AU - Jordan, Michael

AU - Mitchell, Tom

AU - Murakami, Masaaki

AU - Sakamoto, Akemi

AU - Schaefer, Brian C.

AU - Swanson, Bradley

AU - Kappler, John

PY - 2000/8

Y1 - 2000/8

N2 - Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

AB - Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type 1 cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

UR - https://www.scopus.com/pages/publications/5844320555

U2 - 10.1038/77778

DO - 10.1038/77778

M3 - Review article

C2 - 11248801

AN - SCOPUS:5844320555

SN - 1529-2908

VL - 1

SP - 107

EP - 111

JO - Nature Immunology

JF - Nature Immunology

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ER -

Homeostasis of αβ TCR+ T cells

Abstract

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Homeostasis of αβ TCR⁺ T cells