Host determinants of HIV-1 control in African Americans

Kimberly Pelak; David B. Goldstein; Nicole M. Walley; Jacques Fellay; Dongliang Ge; Kevin V. Shianna; Curtis Gumbs; Xiaojiang Gao; Jessica M. Maia; Kenneth D. Cronin; Shehnaz K. Hussain; Mary Carrington; Nelson L. Michael; Amy C. Weintrob

doi:10.1086/651382

Host determinants of HIV-1 control in African Americans

Kimberly Pelak, David B. Goldstein, Nicole M. Walley, Jacques Fellay, Dongliang Ge, Kevin V. Shianna, Curtis Gumbs, Xiaojiang Gao, Jessica M. Maia, Kenneth D. Cronin, Shehnaz K. Hussain, Mary Carrington, Nelson L. Michael, Amy C. Weintrob

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136 Scopus citations

Abstract

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 X 10^-10). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

Original language	English
Pages (from-to)	1141-1149
Number of pages	9
Journal	Journal of Infectious Diseases
Volume	201
Issue number	8
DOIs	https://doi.org/10.1086/651382
State	Published - 15 Apr 2010
Externally published	Yes

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@article{f28c3187b9dd4f40868d9ab589bfbe60,

title = "Host determinants of HIV-1 control in African Americans",

abstract = "We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 X 10-10). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.",

author = "Kimberly Pelak and Goldstein, {David B.} and Walley, {Nicole M.} and Jacques Fellay and Dongliang Ge and Shianna, {Kevin V.} and Curtis Gumbs and Xiaojiang Gao and Maia, {Jessica M.} and Cronin, {Kenneth D.} and Hussain, {Shehnaz K.} and Mary Carrington and Michael, {Nelson L.} and Weintrob, {Amy C.}",

note = "Funding Information: Financial support: Infectious Disease Clinical Research Program (Department of Defense program executed through the Uniformed Services University of the Health Sciences and funded by the National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH], under interagency agreement Y1-AI-5072); NIH (genetics training grant 5 T32 GM007754-29 to K.P.); NIAID Center for HIV/AIDS Vaccine Immunology (grant AI067854); National Cancer Institute (NCI), NIH (contract HHSN261200800001E); Center for Cancer Research, NCI, NIH. The Multicenter AIDS Cohort Study is funded by NIAID with supplemental funding from NCI and the National Heart, Lung, and Blood Institute (grants UO1-AI-35042, 5-M01-RR-00052 [GCRC], UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).",

year = "2010",

month = apr,

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doi = "10.1086/651382",

language = "English",

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pages = "1141--1149",

journal = "Journal of Infectious Diseases",

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T1 - Host determinants of HIV-1 control in African Americans

AU - Pelak, Kimberly

AU - Goldstein, David B.

AU - Walley, Nicole M.

AU - Fellay, Jacques

AU - Ge, Dongliang

AU - Shianna, Kevin V.

AU - Gumbs, Curtis

AU - Gao, Xiaojiang

AU - Maia, Jessica M.

AU - Cronin, Kenneth D.

AU - Hussain, Shehnaz K.

AU - Carrington, Mary

AU - Michael, Nelson L.

AU - Weintrob, Amy C.

N1 - Funding Information: Financial support: Infectious Disease Clinical Research Program (Department of Defense program executed through the Uniformed Services University of the Health Sciences and funded by the National Institute of Allergy and Infectious Diseases [NIAID], National Institutes of Health [NIH], under interagency agreement Y1-AI-5072); NIH (genetics training grant 5 T32 GM007754-29 to K.P.); NIAID Center for HIV/AIDS Vaccine Immunology (grant AI067854); National Cancer Institute (NCI), NIH (contract HHSN261200800001E); Center for Cancer Research, NCI, NIH. The Multicenter AIDS Cohort Study is funded by NIAID with supplemental funding from NCI and the National Heart, Lung, and Blood Institute (grants UO1-AI-35042, 5-M01-RR-00052 [GCRC], UO1-AI-35043, UO1-AI-37984, UO1-AI-35039, UO1-AI-35040, UO1-AI-37613, and UO1-AI-35041).

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N2 - We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 X 10-10). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

AB - We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 X 10-10). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

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VL - 201

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EP - 1149

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

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ER -

Host determinants of HIV-1 control in African Americans

Abstract

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