Host determinants of HIV-1 control in African Americans

Kimberly Pelak, David B. Goldstein, Nicole M. Walley, Jacques Fellay, Dongliang Ge, Kevin V. Shianna, Curtis Gumbs, Xiaojiang Gao, Jessica M. Maia, Kenneth D. Cronin, Shehnaz K. Hussain, Mary Carrington, Nelson L. Michael, Amy C. Weintrob

Research output: Contribution to journalArticlepeer-review

132 Scopus citations

Abstract

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 X 10-10). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.

Original languageEnglish
Pages (from-to)1141-1149
Number of pages9
JournalJournal of Infectious Diseases
Volume201
Issue number8
DOIs
StatePublished - 15 Apr 2010
Externally publishedYes

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