Host genetic influences on HIV-1 pathogenesis

Nelson L. Michael*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.

Original languageEnglish
Pages (from-to)466-474
Number of pages9
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Aug 1999
Externally publishedYes


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