Host genetic influences on HIV-1 pathogenesis

Nelson L. Michael

doi:10.1016/S0952-7915(99)80078-8

Host genetic influences on HIV-1 pathogenesis

Nelson L. Michael^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.

Original language	English
Pages (from-to)	466-474
Number of pages	9
Journal	Current Opinion in Immunology
Volume	11
Issue number	4
DOIs	https://doi.org/10.1016/S0952-7915(99)80078-8
State	Published - Aug 1999
Externally published	Yes

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10.1016/S0952-7915(99)80078-8

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title = "Host genetic influences on HIV-1 pathogenesis",

abstract = "Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.",

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AB - Cellular entry of HIV-1 is mediated by interaction with CD4 and chemokine receptors that serve as entry coreceptors. The immune response against HIV-1 is regulated by genes of the HLA locus. Genetic polymorphisms in these genes have recently been associated with effects on HIV-1 pathogenesis. The history and implications of these discoveries are described in this review.

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Host genetic influences on HIV-1 pathogenesis

Abstract

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