Host response to implanted materials and devices: An overview

Michelle E. Scarritt; Ricardo Londono; Stephen F. Badylak

doi:10.1007/978-3-319-45433-7_1

Host response to implanted materials and devices: An overview

Michelle E. Scarritt, Ricardo Londono, Stephen F. Badylak^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

17 Scopus citations

Abstract

The host response to implanted materials and devices is influenced not only by the design of the material itself, but also by the local and systemic environment of the host. Much of the early response follows the well-described cascade of events of wound healing from hemostasis to scar formation. An implanted material can positively or negatively modulate this cascade of events, culminating in a constructive remodeling response, a persistent inflammatory response, a foreign body response with encapsulation, or an adaptive immune response. An overview of these events, as well as the influence of biologic versus synthetic materials, is discussed in this chapter.

Original language	English
Title of host publication	The Immune Response to Implanted Materials and Devices
Subtitle of host publication	The Impact of the Immune System on the Success of an Implant
Publisher	Springer International Publishing
Pages	1-14
Number of pages	14
ISBN (Electronic)	9783319454337
ISBN (Print)	9783319454313
DOIs	https://doi.org/10.1007/978-3-319-45433-7_1
State	Published - 1 Jan 2016
Externally published	Yes

Keywords

Constructive remodeling
Extracellular matrix
Hemostasis
Host response
Immune response
Leukocyte
Macrophage
Scar

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10.1007/978-3-319-45433-7_1

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abstract = "The host response to implanted materials and devices is influenced not only by the design of the material itself, but also by the local and systemic environment of the host. Much of the early response follows the well-described cascade of events of wound healing from hemostasis to scar formation. An implanted material can positively or negatively modulate this cascade of events, culminating in a constructive remodeling response, a persistent inflammatory response, a foreign body response with encapsulation, or an adaptive immune response. An overview of these events, as well as the influence of biologic versus synthetic materials, is discussed in this chapter.",

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Host response to implanted materials and devices: An overview. / Scarritt, Michelle E.; Londono, Ricardo; Badylak, Stephen F.
The Immune Response to Implanted Materials and Devices: The Impact of the Immune System on the Success of an Implant. Springer International Publishing, 2016. p. 1-14.

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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Host response to implanted materials and devices: An overview

Abstract

Keywords

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