Host response to implanted materials and devices: An overview

Michelle E. Scarritt, Ricardo Londono, Stephen F. Badylak*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

17 Scopus citations


The host response to implanted materials and devices is influenced not only by the design of the material itself, but also by the local and systemic environment of the host. Much of the early response follows the well-described cascade of events of wound healing from hemostasis to scar formation. An implanted material can positively or negatively modulate this cascade of events, culminating in a constructive remodeling response, a persistent inflammatory response, a foreign body response with encapsulation, or an adaptive immune response. An overview of these events, as well as the influence of biologic versus synthetic materials, is discussed in this chapter.

Original languageEnglish
Title of host publicationThe Immune Response to Implanted Materials and Devices
Subtitle of host publicationThe Impact of the Immune System on the Success of an Implant
PublisherSpringer International Publishing
Number of pages14
ISBN (Electronic)9783319454337
ISBN (Print)9783319454313
StatePublished - 1 Jan 2016
Externally publishedYes


  • Constructive remodeling
  • Extracellular matrix
  • Hemostasis
  • Host response
  • Immune response
  • Leukocyte
  • Macrophage
  • Scar


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