Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use

Joseph Burke*, Mark C.P. Haigney, Morteza Farasat, Philip S. Mehler, Mori J. Krantz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Many volatile chemicals inhaled for a recreational high have a chemical structure similar to chloroform and may lead to Ikr blockade and subsequent torsades de pointes. This is one potential mechanism of action for huffing-associated sudden death.

Original languageEnglish
JournalClinical Case Reports
Volume9
Issue number8
DOIs
StatePublished - Aug 2021
Externally publishedYes

Keywords

  • Ikr
  • hERG
  • huffing
  • sudden cardiac death
  • torsade de pointes

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