Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use

Joseph Burke; Mark C.P. Haigney; Morteza Farasat; Philip S. Mehler; Mori J. Krantz

doi:10.1002/ccr3.3838

Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use

Joseph Burke^*, Mark C.P. Haigney, Morteza Farasat, Philip S. Mehler, Mori J. Krantz

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Many volatile chemicals inhaled for a recreational high have a chemical structure similar to chloroform and may lead to Ikr blockade and subsequent torsades de pointes. This is one potential mechanism of action for huffing-associated sudden death.

Original language	English
Journal	Clinical Case Reports
Volume	9
Issue number	8
DOIs	https://doi.org/10.1002/ccr3.3838 https://doi.org/10.1002/ccr3.3838
State	Published - Aug 2021
Externally published	Yes

Keywords

Ikr
hERG
huffing
sudden cardiac death
torsade de pointes

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title = "Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use",

abstract = "Many volatile chemicals inhaled for a recreational high have a chemical structure similar to chloroform and may lead to Ikr blockade and subsequent torsades de pointes. This is one potential mechanism of action for huffing-associated sudden death.",

keywords = "Ikr, hERG, huffing, sudden cardiac death, torsade de pointes",

author = "Joseph Burke and Haigney, {Mark C.P.} and Morteza Farasat and Mehler, {Philip S.} and Krantz, {Mori J.}",

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year = "2021",

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language = "English",

volume = "9",

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AU - Burke, Joseph

AU - Haigney, Mark C.P.

AU - Farasat, Morteza

AU - Mehler, Philip S.

AU - Krantz, Mori J.

PY - 2021/8

Y1 - 2021/8

N2 - Many volatile chemicals inhaled for a recreational high have a chemical structure similar to chloroform and may lead to Ikr blockade and subsequent torsades de pointes. This is one potential mechanism of action for huffing-associated sudden death.

AB - Many volatile chemicals inhaled for a recreational high have a chemical structure similar to chloroform and may lead to Ikr blockade and subsequent torsades de pointes. This is one potential mechanism of action for huffing-associated sudden death.

KW - Ikr

KW - hERG

KW - huffing

KW - sudden cardiac death

KW - torsade de pointes

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U2 - 10.1002/ccr3.3838

DO - 10.1002/ccr3.3838

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SN - 2050-0904

VL - 9

JO - Clinical Case Reports

JF - Clinical Case Reports

IS - 8

ER -

Huffing and twist: Fatal Torsade de pointes associated with Tetrafluoroethane Inhalation and amphetamine use

Abstract

Keywords

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