Human dendritic cells as targets of dengue virus infection

Mary Marovich*, Geraldine N. Grouard-Vogel, Mark Louder, Michael Eller, Wellington Sun, Shuenn Ju Wu, Ravithat Putvatana, Gerald Murphy, Boonrat Tassaneetrithep, Timothy Burgess, Deborah Birx, Curtis Hayes, Sarah Schlesinger-Frankel, John Mascola

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

137 Scopus citations


Dengue virus infections are an emerging global threat. Severe dengue infection is manifested as dengue hemorrhagic fever and dengue shock syndrome, both of which can be fatal complications. Factors predisposing to complicated disease and pathogenesis of severe infections are discussed. Using immunohistochemistry, immunofluorescence, flow cytometry, and ELISA techniques, we studied the cellular targets of dengue virus infection, at both the clinical (in vivo) and the laboratory (in vitro) level. Resident skin dendritic cells are targets of dengue virus infection as demonstrated in a skin biopsy from a dengue vaccine recipient. We show that factors influencing infection of monocytes/macrophages and dendritic cells are different. Immature dendritic cells were found to be the cells most permissive for dengue infection and maybe early targets for infection. Immature dendritic cells exposed to dengue virus produce TNF-α protein. Some of these immature dendritic cells undergo TNF-α mediated maturation as a consequence of exposure to the dengue virus.

Original languageEnglish
Pages (from-to)219-224
Number of pages6
JournalJournal of Investigative Dermatology Symposium Proceedings
Issue number3
StatePublished - 2001
Externally publishedYes


  • Hemorrhagic virus infects APC


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