Human Renal Allograft Rejection Despite the Absence of Allogeneic Passenger Leukocytes

Edwin H. Preston*, Jimmy A. Light, Robert L. Kampen, Allan D. Kirk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Passenger leukocytes have been suggested to be both pro-tolerant and immunogenic. The opportunity to evaluate the role of allogeneic passenger leukocytes in humans was presented by a 47-year-old man who donated bone marrow to his HLA-identical leukemic sister. Eleven years later he developed renal failure. The sister's marrow was noted to be 100% XY karyotype and free of malignancy. She donated a kidney to her brother. Immunosuppression was tapered following transplantation. After 6 months, the recipient was on monotherapy sirolimus, 1 mg every third day. A surveillance biopsy was normal and sirolimus was stopped. Eight weeks later, he presented with severe rejection that reversed with Thymoglobulin. Renal function returned to baseline and has been stable on conventional immunosuppression.

Original languageEnglish
Pages (from-to)283-285
Number of pages3
JournalAmerican Journal of Transplantation
Issue number2
StatePublished - Feb 2004
Externally publishedYes


  • Allorecognition
  • Kidney transplantation
  • Leukocytes
  • Minor histocompatibility antigens


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