@article{a9c9d01f9ef24dcb8f7f0c03290b020d,
title = "Human serum with high neutralizing antibody titers against both Zika and dengue virus shows delayed in vitro antibody-dependent enhancement of dengue virus infection",
abstract = "Zika virus infection in a dengue virus-na{\"i}ve subject was associated with the induction of high levels of cross-reactive binding antibodies. These responses were, however, largely non-neutralizing and displayed a capacity to enhance dengue infection in vitro at significantly low dilution (1:10). In contrast, a subject who had high levels of neutralizing antibodies against both dengue and Zika viruses enhanced infection at a dilution of 1:10 000. These results suggest that high levels of dengue cross-neutralizing antibodies could potentially prevent the enhancement of dengue infection in Zika virus-convalescent individuals.",
keywords = "Antibody-dependent enhancement, Cross-neutralization, Dengue virus, Zika virus",
author = "Valiant, {William G.} and Tahaniyat Lalani and Yun, {Heather C.} and Anjali Kunz and Burgess, {Timothy H.} and Mattapallil, {Joseph J.}",
note = "Funding Information: Financial support. The described project was supported by funds from the Uniformed Services University to J.J.M. The serum samples were derived from the Deployment and Travel Related Infectious Disease Risk Assessment, Outcomes, and Prevention Strategies among Department of Defense Beneficiaries (TravMil) study, supported by the Infectious Disease Clinical Research Program (IDCRP), a Department of Defense (DoD) program executed through the Uniformed Services University of the Health Sciences, the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), under the Inter-Agency Agreement Y1-AI-5072. Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2018",
month = jul,
day = "1",
doi = "10.1093/ofid/ofy151",
language = "English",
volume = "5",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
number = "7",
}