Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein

Elizabeth Jaworski; Aarthi Narayanan; Rachel Van Duyne; Shabana Shabbeer-Meyering; Sergey Iordanskiy; Mohammed Saifuddin; Ravi Das; Philippe V. Afonso; Gavin C. Sampey; Myung Chung; Anastas Popratiloff; Bindesh Shrestha; Mohit Sehgal; Pooja Jain; Akos Vertes; Renaud Mahieux; Fatah Kashanchi

doi:10.1074/jbc.M114.549659

Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein

Elizabeth Jaworski
, Aarthi Narayanan
, Rachel Van Duyne
, Shabana Shabbeer-Meyering
, Sergey Iordanskiy
, Mohammed Saifuddin
, Ravi Das
, Philippe V. Afonso
, Gavin C. Sampey
, Myung Chung
, Anastas Popratiloff
, Bindesh Shrestha
, Mohit Sehgal
, Pooja Jain
, Akos Vertes
, Renaud Mahieux
, Fatah Kashanchi^*

^*Corresponding author for this work

Pharmacology and Molecular Therapeutics

Research output: Contribution to journal › Article › peer-review

146 Scopus citations

Abstract

Background: Extracellular exosomes contain various functional elements. Results: Exosomal Tax protein causes phenotypic changes in uninfected cells. Conclusion: Exosomes may play critical roles in extracellular delivery of oncogenic material derived from HTLV-1-infected cells. Significance: Exosomal delivery of Tax and other putative oncogenic components produced during HTLV-1 infection potentially contributes to pathogenesis of adult T-cell leukemia, myelopathy, or tropical spastic paraparesis.

Original language	English
Pages (from-to)	22284-22305
Number of pages	22
Journal	Journal of Biological Chemistry
Volume	289
Issue number	32
DOIs	https://doi.org/10.1074/jbc.M114.549659
State	Published - 8 Aug 2014

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Jaworski, E., Narayanan, A., Van Duyne, R., Shabbeer-Meyering, S., Iordanskiy, S., Saifuddin, M., Das, R., Afonso, P. V., Sampey, G. C., Chung, M., Popratiloff, A., Shrestha, B., Sehgal, M., Jain, P., Vertes, A., Mahieux, R., & Kashanchi, F. (2014). Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein. Journal of Biological Chemistry, 289(32), 22284-22305. https://doi.org/10.1074/jbc.M114.549659

@article{dee03491d8284e8fb27578330ce9fb0f,

title = "Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein",

abstract = "Background: Extracellular exosomes contain various functional elements. Results: Exosomal Tax protein causes phenotypic changes in uninfected cells. Conclusion: Exosomes may play critical roles in extracellular delivery of oncogenic material derived from HTLV-1-infected cells. Significance: Exosomal delivery of Tax and other putative oncogenic components produced during HTLV-1 infection potentially contributes to pathogenesis of adult T-cell leukemia, myelopathy, or tropical spastic paraparesis.",

author = "Elizabeth Jaworski and Aarthi Narayanan and \{Van Duyne\}, Rachel and Shabana Shabbeer-Meyering and Sergey Iordanskiy and Mohammed Saifuddin and Ravi Das and Afonso, \{Philippe V.\} and Sampey, \{Gavin C.\} and Myung Chung and Anastas Popratiloff and Bindesh Shrestha and Mohit Sehgal and Pooja Jain and Akos Vertes and Renaud Mahieux and Fatah Kashanchi",

year = "2014",

month = aug,

day = "8",

doi = "10.1074/jbc.M114.549659",

language = "English",

volume = "289",

pages = "22284--22305",

journal = "Journal of Biological Chemistry",

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}

Jaworski, E, Narayanan, A, Van Duyne, R, Shabbeer-Meyering, S, Iordanskiy, S, Saifuddin, M, Das, R, Afonso, PV, Sampey, GC, Chung, M, Popratiloff, A, Shrestha, B, Sehgal, M, Jain, P, Vertes, A, Mahieux, R & Kashanchi, F 2014, 'Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein', Journal of Biological Chemistry, vol. 289, no. 32, pp. 22284-22305. https://doi.org/10.1074/jbc.M114.549659

TY - JOUR

T1 - Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein

AU - Jaworski, Elizabeth

AU - Narayanan, Aarthi

AU - Van Duyne, Rachel

AU - Shabbeer-Meyering, Shabana

AU - Iordanskiy, Sergey

AU - Saifuddin, Mohammed

AU - Das, Ravi

AU - Afonso, Philippe V.

AU - Sampey, Gavin C.

AU - Chung, Myung

AU - Popratiloff, Anastas

AU - Shrestha, Bindesh

AU - Sehgal, Mohit

AU - Jain, Pooja

AU - Vertes, Akos

AU - Mahieux, Renaud

AU - Kashanchi, Fatah

PY - 2014/8/8

Y1 - 2014/8/8

N2 - Background: Extracellular exosomes contain various functional elements. Results: Exosomal Tax protein causes phenotypic changes in uninfected cells. Conclusion: Exosomes may play critical roles in extracellular delivery of oncogenic material derived from HTLV-1-infected cells. Significance: Exosomal delivery of Tax and other putative oncogenic components produced during HTLV-1 infection potentially contributes to pathogenesis of adult T-cell leukemia, myelopathy, or tropical spastic paraparesis.

AB - Background: Extracellular exosomes contain various functional elements. Results: Exosomal Tax protein causes phenotypic changes in uninfected cells. Conclusion: Exosomes may play critical roles in extracellular delivery of oncogenic material derived from HTLV-1-infected cells. Significance: Exosomal delivery of Tax and other putative oncogenic components produced during HTLV-1 infection potentially contributes to pathogenesis of adult T-cell leukemia, myelopathy, or tropical spastic paraparesis.

UR - https://www.scopus.com/pages/publications/84905833500

U2 - 10.1074/jbc.M114.549659

DO - 10.1074/jbc.M114.549659

M3 - Article

C2 - 24939845

AN - SCOPUS:84905833500

SN - 0021-9258

VL - 289

SP - 22284

EP - 22305

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 32

ER -

Human T-lymphotropic virus type 1-infected cells secrete exosomes that contain tax protein

Abstract

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