TY - JOUR
T1 - Hyaline globules in mammary myofibroblastoma
T2 - A case report
AU - Ozerdem, Ugur
AU - Wells, Justin
AU - Hoda, Syed A.
N1 - Publisher Copyright:
© The Author(s) 2014.
PY - 2015/2/13
Y1 - 2015/2/13
N2 - A 52-year-old otherwise healthy woman presented with a solitary firm mass in the right breast. Histopathological evaluation of the 1.5-cm mass showed a mammary myofibroblastoma of the conventional spindle-cell type. High-power examination of hematoxylin-eosin-stained sections showed round, eosinophilic, intracytoplasmic, as well as extracellular, hyaline globules. These 5- to 20-μm globules appeared gray with a pinkish rim on Masson's trichrome stain. Immunohistochemically, the hyaline globules were strongly reactive with smooth muscle myosin heavy chain, desmin, and caldesmon. Histologically similar inclusion bodies have been reported in phylloides tumors - including those with myoid differentiation. To our knowledge, this is the first description of hyaline globules, a peculiar histological curiosity with no known clinical significance, in mammary myofibroblastoma.
AB - A 52-year-old otherwise healthy woman presented with a solitary firm mass in the right breast. Histopathological evaluation of the 1.5-cm mass showed a mammary myofibroblastoma of the conventional spindle-cell type. High-power examination of hematoxylin-eosin-stained sections showed round, eosinophilic, intracytoplasmic, as well as extracellular, hyaline globules. These 5- to 20-μm globules appeared gray with a pinkish rim on Masson's trichrome stain. Immunohistochemically, the hyaline globules were strongly reactive with smooth muscle myosin heavy chain, desmin, and caldesmon. Histologically similar inclusion bodies have been reported in phylloides tumors - including those with myoid differentiation. To our knowledge, this is the first description of hyaline globules, a peculiar histological curiosity with no known clinical significance, in mammary myofibroblastoma.
KW - Breast
KW - Hyaline globule
KW - Inclusion bodies
KW - Myofibroblastoma
UR - http://www.scopus.com/inward/record.url?scp=84920848762&partnerID=8YFLogxK
U2 - 10.1177/1066896914525235
DO - 10.1177/1066896914525235
M3 - Article
C2 - 24583838
AN - SCOPUS:84920848762
SN - 1066-8969
VL - 23
SP - 89
EP - 91
JO - International Journal of Surgical Pathology
JF - International Journal of Surgical Pathology
IS - 1
ER -