TY - JOUR
T1 - Hypocalcemia complicating deferoxamine therapy in an infant with parenteral nutrition-associated aluminum overload
T2 - Evidence for a role of aluminum in the bone disease of infants
AU - Klein, Gordon L.
AU - Snodgrass, Wayne R.
AU - Griffin, M. Pamela
AU - Miller, Nancy L.
AU - Alfrey, Allen C.
PY - 1989/10
Y1 - 1989/10
N2 - Aluminum (Al) contaminates total parenteral nutrition (TPN) solutions given to infants, and high levels of Al have been demonstrated in their bone, serum, and urine. However, it is uncertain whether Al at current levels of contamination of TPN solutions is harmful to bone. We report an 8-month-old infant who developed os-teopenic bone disease while receiving TPN, which did not respond to large amounts of calcium, phosphate, and vitamin D2. Serum and urine Al levels were greatly elevated and fell after a short course of deferoxamine. However, shortly after treatment began, serum calcium levels fell in the absence of hypercalciuria. We postulate that chelation of Al from this patient’s bone permitted increased bone calcium uptake. This would suggest that Al at current levels of contamination of TPN solutions may impair bone calcium uptake and thus contribute to the pathogenesis or exacerbation of TPN-related osteopenia.
AB - Aluminum (Al) contaminates total parenteral nutrition (TPN) solutions given to infants, and high levels of Al have been demonstrated in their bone, serum, and urine. However, it is uncertain whether Al at current levels of contamination of TPN solutions is harmful to bone. We report an 8-month-old infant who developed os-teopenic bone disease while receiving TPN, which did not respond to large amounts of calcium, phosphate, and vitamin D2. Serum and urine Al levels were greatly elevated and fell after a short course of deferoxamine. However, shortly after treatment began, serum calcium levels fell in the absence of hypercalciuria. We postulate that chelation of Al from this patient’s bone permitted increased bone calcium uptake. This would suggest that Al at current levels of contamination of TPN solutions may impair bone calcium uptake and thus contribute to the pathogenesis or exacerbation of TPN-related osteopenia.
KW - Aluminum contamination
KW - Osteopenia
KW - Total parenteral nutrition
UR - http://www.scopus.com/inward/record.url?scp=0024461127&partnerID=8YFLogxK
U2 - 10.1097/00005176-198910000-00024
DO - 10.1097/00005176-198910000-00024
M3 - Article
C2 - 2515268
AN - SCOPUS:0024461127
SN - 0277-2116
VL - 9
SP - 400
EP - 403
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
IS - 3
ER -